Hydrogen Therapy Helps Complex Autoimmune Disease Patient Feel Better
Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction
Research hubs: Chronic Fatigue · Immune System · Respiratory System
- Evidence type
- Case report or series · Human study
- Authors
- Ying-Hsuan Tsai, Jeng-Wei Lu, Jou-I Tu, Yuan-Ju Li, Hui-Fu Hsu, Feng-Hao Chang, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Kuang-Yih Wang, Feng-Cheng Liu
- Journal
- In Vivo
- Year
- 2025
- PMID
- 40579023
- Study Type
- Human
- Participants
- 1
- Delivery
- Gas (Sustained Release)
- Dose
- One hydrogen capsule daily (170 mg hydrogen-enriched calcium per capsule) in combination with high-dose vitamin C supplementation
- Funding
- National Science and Technology Council, Taiwan (NSTC 112-2314-B-016-033); National Science and Technology Council, Taiwan (NSTC 113-2314-B-016-052); Tri-Service General Hospital, Taiwan (TSGH-E-112218); Tri-Service General Hospital, Taiwan (TSGH-E-113238)
- Conflicts of interest
- None declared
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 2 (OpenAlex, as of November 2026)
- Country
- Taiwan
TL;DR
Breathing in molecular hydrogen helped improve symptoms and immune function in a patient with overlapping autoimmune diseases.
Key Finding
A single patient with overlapping autoimmune diseases reported significant symptom improvement and favorable changes in immune markers after receiving molecular hydrogen therapy as an add-on treatment.
Summary
This case report describes one 69-year-old woman with three overlapping autoimmune diseases (Sjögren's syndrome, lupus, and lung inflammation) who received molecular hydrogen therapy alongside her regular medications. Over several months, she reported improvements in dry mouth, dry eyes, sleep problems, and shortness of breath, along with changes in blood markers related to immune function and reduced fatigue, which allowed her to reduce her corticosteroid dose.
Practical Takeaway
While this case report suggests molecular hydrogen may have potential as a complementary therapy for certain autoimmune conditions, it describes only one patient and lacks comparison to a control group. Much larger, well-designed studies are needed before any conclusions can be drawn about effectiveness. Anyone considering hydrogen therapy should discuss it with their doctor, especially since this patient was also taking other treatments including vitamin C.
Abstract (excerpt)
Background/aim: Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are chronic autoimmune diseases that often coexist. They share features such as systemic inflammation and multi-organ involvement and typically require long-term immunosuppressive treatment. However, long-term use…