New Metabiotics Technology Could Replace Traditional Probiotics
METABIOTICS - NOVEL TECHNOLOGY OF PROTECTIVE AND TREATMENT OF DISEASES ASSOCIATED WITH MICROECOLOGICAL IMBALANCE IN HUMAN BEING
Research hubs: Digestive System · Endocrine System
- Evidence type
- Review or commentary
- Authors
- B. A. Shenderov, E.I. Tkachenko, L.B. Lazebnik, M.D. Ardatskaya, A.V. Sinitsa, M.M. Zakharenko
- Journal
- Experimental and Clinical Gastroenterology
- Year
- 2018
- Study Type
- clinical
- Peer Reviewed
- Yes
- Cited by
- 22 (OpenAlex, as of November 2026)
- Country
- Russia
TL;DR
Scientists found that special molecules made by good bacteria in your gut could be better than regular probiotics at fixing an unhealthy gut and helping your body stay healthy, because these molecules work longer and have fewer side effects. This could help treat lots of diseases caused by having the wrong balance of bacteria in your body.
Summary
Scientists introduced metabiotics, a new technology using bioactive molecules derived from probiotic microorganisms and their metabolites. Unlike traditional probiotics, which often provide short-term or uncertain benefits, metabiotics offer defined chemical structures, precise dosing, enhanced safety, and longer shelf life. These compounds work by restoring the balance between host cells and beneficial microbes, potentially optimizing gene expression and multiple physiological systems including immune, metabolic, and neuro-hormonal functions. Metabiotics can be used independently or added to functional foods, with potential applications in personalized medicine for treating diseases associated with microbiome imbalances.
Abstract (excerpt)
The human symbiotic microbiota produces various bio-active molecules having chemical and functional similarity to dietary nutrients and /or endogenous compounds. Various factors and agents cause the imbalance of host/microbial dialogue. Currently for conservation and restoration of human microbial…