Hydrogen Water During Pregnancy Protects Baby's Brain Development
- Authors
- Yukio Mano, Tomomi Kotani, Mikako Ito, Taku Nagai, Yuko Ichinohashi, Kiyofumi Yamada, Kinji Ohno, Fumitaka Kikkawa, Shinya Toyokuni
- Journal
- Free Radical Biology and Medicine
- Year
- 2014
- DOI
- 10.1016/j.freeradbiomed.2014.01.037
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Japan
- Health Condition
- Ischemia-Reperfusion Injury
- Body System
- Nervous System
TL;DR
Drinking hydrogen-rich water during pregnancy can help protect unborn rats' brains from damage caused by a temporary lack of blood supply.
Key Finding
Maternal hydrogen-saturated water administration reduced oxidative stress markers in fetal brain tissue and preserved memory function in offspring exposed to placental blood flow interruption during pregnancy.
Summary
In this rat study, pregnant mothers were given hydrogen-saturated water starting before an induced blood flow interruption to the fetus on day 16 of pregnancy. Researchers found that hydrogen reduced damage markers in the placenta and fetal brain (specifically the hippocampus, which is involved in memory), prevented growth problems in newborns, and helped preserve memory function in the offspring when tested 8 weeks later.
Practical Takeaway
This is an animal study only, so findings cannot be directly applied to humans. Early evidence suggests hydrogen water may have neuroprotective properties against placental injury, but human research would be needed to determine if this applies to pregnant women. The study does not support any current health claims for hydrogen water in pregnancy without further human evidence.
Abstract
Molecular hydrogen (H2) scavenges hydroxyl radicals. Recently, H2 has been reported to prevent a variety of diseases associated with oxidative stress in model systems and in humans. Here, we studied the effects of H2 on rat fetal hippocampal damage caused by ischemia and reperfusion (IR) on day 16 of pregnancy with the transient occlusion of the bilateral utero-ovarian arteries. Starting 2 days before the operation, we provided the mothers with hydrogen-saturated water ad libitum until vaginal delivery. We observed a significant increase in the concentration of H2 in the placenta after the oral administration of hydrogen-saturated water to the mothers, with less placental oxidative damage after IR in the presence of H2. Neonatal growth retardation was observed in the IR group, which was alleviated by the H2 administration. We analyzed the neuronal cell damage in the CA1 and CA3 areas of the hippocampus at day 7 after birth by immunohistochemical analysis of the 8-oxo-7,8-dihydro-2׳-deoxyguanosine- and 4-hydroxy-2-nonenal-modified proteins. Both oxidative stress markers were significantly increased in the IR group, which was again ameliorated by the H2 intake. Last, 8-week-old rats were subjected to a Morris water maze test. Maternal H2 administration improved the reference memory of the offspring to the sham level after IR injury during pregnancy. Overall, the present results support the idea that maternal H2 intake helps prevent the hippocampal impairment of offspring induced by IR during pregnancy.