Local generation of hydrogen for enhanced photothermal therapy
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DOI:
10.1038/s41467-018-06630-2
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Abstract:
By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here we utilize the cubic PdH0.2 nanocrystals for tumour-targeted and photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer. The synthesized PdH0.2 nanocrystals have exhibited high intratumoural accumulation capability, clear NIR-controlled hydrogen release behaviours, NIR-enhanced self-catalysis bio-reductivity, high NIR-photothermal effect and PAI performance. With these unique properties of PdH0.2 nanocrystals, synergetic hydrogenothermal therapy with limited systematic toxicity has been achieved by tumour-targeted delivery and PAI-guided NIR-controlled release of bio-reductive hydrogen as well as generation of heat. This hydrogenothermal approach has presented a cancer-selective strategy for synergistic cancer treatment.| Publish Year | 2018 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Nature Communications |
| Primary Topic | Whole Body |
| Secondary Topic | Cancer |
| Model | Cell Culture |
| Tertiary Topic | Novel Therapy |
| Vehicle | Gas (Sustained Release) |
| pH | N/A |
| Application | Implantation |
| Comparison | |
| Complement |