Hydrogen Water Protects Against Radiation Gut Damage in Mice
Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota
Research hubs: Immune System · Digestive System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (mouse)
- Authors
- Hui-Wen Xiao, Yuan Li, Dan Luo, Jia-Li Dong, Li-Xin Zhou, Shu-Yi Zhao, Qi-Sheng Zheng, Hai-Chao Wang, Ming Cui, Sai-Jun Fan
- Journal
- Experimental & Molecular Medicine
- Year
- 2018
- PMID
- 29371696
- Study Type
- Mouse
- Delivery
- Water (Dissolved)
- Dose
- oral gavage with hydrogen-water
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
TL;DR
Drinking hydrogen-infused water helped mice recover from intestinal damage caused by radiation therapy for abdominal cancers.
Key Finding
Hydrogen water increased survival rates and improved intestinal function in mice exposed to abdominal radiation, potentially by protecting the gut lining and preserving beneficial bacteria.
Summary
Researchers gave mice hydrogen-infused water before exposing them to radiation therapy targeting the abdomen. The hydrogen water helped mice survive longer, maintain body weight, and protected the lining of their small intestines from radiation damage. The study suggests hydrogen water works by changing how certain genes are expressed and by preserving beneficial bacteria in the gut.
Practical Takeaway
This is early-stage research conducted only in mice, so it cannot yet be applied to human cancer patients. While the results are promising, human studies would be needed to determine if hydrogen water could help reduce radiation side effects in people undergoing cancer treatment. Anyone undergoing radiation therapy should discuss any supplements with their oncologist before use.
Abstract (excerpt)
Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens…