Hydrogen Water Protects Against Noise-Induced Hearing Loss in Study
- Authors
- Liwei Chen, Ning Yu, Yan Lu, Longjun Wu, Daishi Chen, Weiwei Guo, Lidong Zhao, Mingbo Liu, Shiming Yang, Xuejun Sun, Suoqiang Zhai
- Journal
- PLoS One
- Year
- 2014
- DOI
- 10.1371/journal.pone.0100774
- Study Type
- Guinea Pig
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Noise-Induced Hearing Loss
- Body System
- Auditory System
TL;DR
A special saltwater solution containing hydrogen can protect guinea pigs' ears from damage caused by very loud noise.
Key Finding
Hydrogen-saturated saline significantly reduced noise-induced hearing loss and inner ear hair cell damage in guinea pigs, with the protective effect linked to reduced levels of harmful free radicals in the cochlea.
Summary
Researchers tested whether hydrogen-saturated saline (a salt solution containing dissolved hydrogen gas) could protect guinea pigs' hearing from damage caused by loud noise exposure. Guinea pigs that received hydrogen-saturated saline injections before and during loud noise exposure had less hearing damage and fewer damaged hair cells in their inner ears compared to control groups. The hydrogen appeared to work by reducing harmful molecules called free radicals that are produced by noise trauma.
Practical Takeaway
This animal study suggests hydrogen-saturated saline may help protect hearing from noise damage through antioxidant mechanisms, but the findings are limited to guinea pigs and would need to be tested in humans before any clinical recommendations could be made. The study used injections rather than drinking hydrogen water, so it's unclear whether oral hydrogen water would have similar effects.
Abstract
The purpose of the current study was to evaluate hydrogen-saturated saline protecting intensive narrow band noise-induced hearing loss. Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections (1 ml/100 g) 3 days before and 1 h before narrow band noise exposure (2.5-3.5 kHz 130 dB SPL, 1 h). The guinea pigs in the control group received no treatment. The hearing function was assessed by the auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) recording. The changes of free radicals in the cochlea before noise exposure, and immediately and 7 days after noise exposure were also examined. By Scanning electron microscopy and succinate dehydrogenase staining, we found that pre-treatment with hydrogen-saturated saline significantly reduced noise-induced hair cell damage and hearing loss. We also found that the malondialdehyde, lipid peroxidation, and hydroxyl levels were significantly lower in the hydrogen-saturated saline group after noise trauma, indicating that hydrogen-saturated saline can decrease the amount of harmful free radicals caused by noise trauma. Our findings suggest that hydrogen-saturated saline is effective in preventing intensive narrow band noise-induced hearing loss through the antioxidant effect.