Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney
Masanori Katakura, Michio Hashimoto, Osamu Shido, Yoko Tanabe
Read more:
DOI:
10.1186/2045-9912-2-18
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Reactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction in patients with type 2 diabetes and metabolic syndrome. Hydrogen-rich water (HRW) increases the H2 level in blood and tissues, thus reducing oxidative stress in animals as well as humans. In this study, we investigated the effects of HRW on glucose- and α,β-dicarbonyl compound-induced ROS generation in vitro and in vivo. Kidney homogenates from Wistar rats were incubated in vitro with glucose and α,β-dicarbonyl compounds containing HRW, following which ROS levels were measured. In vivo animal models of metabolic syndrome, SHR.Cg-Leprcp/NDmcr rats, were treated with HRW for 16 weeks, following which renal ROS production and plasma and renal α,β-dicarbonyl compound levels were measured by liquid chromatograph mass spectrometer. HRW inhibited glucose- and α,β-dicarbonyl compound-induced ROS production in kidney homogenates from Wistar rats in vitro. Furthermore, SHR.Cg-Leprcp/NDmcr rats treated with HRW showed a 34% decrease in ROS production. Moreover, their renal glyoxal, methylglyoxal, and 3-deoxyglucosone levels decreased by 81%, 77%, and 60%, respectively. Positive correlations were found between renal ROS levels and renal glyoxal (r = 0.659, p = 0.008) and methylglyoxal (r = 0.782, p = 0.001) levels. These results indicate that HRW inhibits the production of α,β-dicarbonyl compounds and ROS in the kidneys of SHR.Cg-Leprcp/NDmcr rats. Therefore, it has therapeutic potential for renal dysfunction in patient with type 2 diabetes and metabolic syndrome.
| Publish Year |
2012 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Medical Gas Research |
| Primary Topic |
Kidney |
| Secondary Topic | Diabetes (Type II) |
| Model |
Rat |
| Tertiary Topic | Diabetic Nephropathy |
| Vehicle |
Water (Mg-Chemico) |
| pH |
Alkaline |
| Application |
Ingestion |
| Comparison |
|
| Complement |
|
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery
2023 - Kidney - Surgery/Transplantation
Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied to cardiac surgery due to its ability to reduce ...
Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the ...
2022 - Kidney - Acute Kidney Injury
Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and ...
Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and ...
2023 - Kidney - Acute Kidney Injury
Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory response and apoptosis are recognized to play important roles in ...
Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: ...
2023 - Whole Body - Diabetes (Type II)
Aim: To evaluate the real-life effectiveness and safety of Chinese patients with type 2 diabetes mellitus (T2DM) receiving hydrogen inhalation (HI) treatment as a supplementary treatment. Methods: This retrospective, multicenter, observational ...
Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes ...
2023 - Whole Body - Diabetes (Type II)
Aim: To analyze the effectiveness and safety of hydrogen inhalation (HI) therapy as an adjunct treatment in Chinese type 2 diabetes mellitus (T2DM) patients in a real-life clinical setting. Methods: This observational, non-interventional, ...
The Effects of Alkaline Ionized Water Administration to the Total Cholesterol Levels in Patients ...
2021 - Whole Body - Diabetes (Type II)
Background: Total cholesterol is a measure of the total amount of cholesterol components including LDL (low-density lipoprotein), HDL (high-density lipoprotein), and VLDL (very low-density lipoprotein). Alkaline ionized water (AIW) is an electrolyzed ...