Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance

Chen Hou, Chuan Qin, Fan Fan, Jiangang Long, Jiankang Liu, Yunhua Peng

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DOI: 10.1080/10715762.2018.1460749 DOI is the universal ID for this study.

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Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ injection-induced cognitive dysfunction. However, whether and how hydrogen affects AD pathogenesis remains uninvestigated. Thus, in the present study, APPswe/PS1dE9 (amyloid precursor protein (APP)/PS1) mice, a transgenic AD mouse model, were administered hydrogen-rich water for 3 months and the effects on cognitive function and molecular pathways were investigated. We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Aβ clearance, and reversed the brain oestrogen level, ERβ, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males. Furthermore, hydrogen-rich water ameliorated oxidative stress and inflammatory responses more profoundly in the brains of female AD mice than in those of males. Our results demonstrate a novel sex-specific beneficial effect of hydrogen via oestrogen and brain ERβ-BDNF signalling in AD pathogenesis.

Publish Year 2018
Country China
Rank Positive
Journal Free Radical Research
Primary Topic Brain
Secondary TopicAlzheimer's Disease
Model Mouse
Tertiary TopicAmyloid Beta Toxicity
Vehicle Water (Dissolved)
pH Neutral
Application Gavage