Hydrogen Water Protects Memory from Toxic Chemical Damage in Mice
- Authors
- Tailai Zhou, Minghao Zhang, Hang Du, Arzu Ablimit, Renyi Ye, Mingqi Lǚ, Xiaojuan Chang, Qi Zhao, Yan Wang, Qizhong Qin
- Journal
- Research Square
- Year
- 2020
- DOI
- 10.21203/rs.2.23352/v1
- Study Type
- Mouse
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Memory Impairment
- Body System
- Nervous System
TL;DR
Drinking hydrogen-rich water improved memory and reduced brain damage in mice exposed to a toxic tin compound.
Key Finding
Hydrogen-rich water pretreatment reduced learning and memory impairment caused by trimethyltin exposure in mice, while also decreasing toxic chemical accumulation and harmful protein levels in the brain.
Summary
Researchers exposed mice to trimethyltin, a toxic chemical that damages the brain and impairs learning and memory. They found that mice given hydrogen-rich water before the toxic exposure performed better on memory tests and showed less brain damage, including lower levels of a harmful protein and reduced accumulation of the toxic chemical in the brain.
Practical Takeaway
This is an early-stage animal study showing hydrogen-rich water may have protective effects against a specific type of brain toxin. However, the study was conducted only in mice, and it's unclear whether these results would apply to humans or to real-world exposures. Much more research would be needed before drawing any conclusions about hydrogen water's usefulness for human health.
Abstract
Abstract Background: As an important member of organic tin compounds, Trimethyltin (TMT) exists widely in industrial and agricultural productions. TMT can induce significant neurodegeneration in the limbic system, particular in hippocampus. However, the molecular mechanisms in TMT-induced learning and memory impairment are not fully clear. Thus, this research was to explore the role of Synaptophysin (SYP) and Ubiquitin-ligating enzyme Siah-1 in TMT-induced nerve impairment and the protective effect of hydrogen rich water (HRW). Methods: Male BALB/c mice were randomly divided into 4 groups: control group (saline, 4 ml/d, i.p.for seven days), HRW group (4 ml/d, i.p.for seven days) , TMT group (2.25mg/kg, i.p. at the seventh day ), and HRW plus TMT group. The spatial learning and memory was tested by Morris water maze, the protein level of SYP and Siah-1were determined by western blot& immunocytochemical analysis, and the tin contents were detected by ICP-MS. Results: The TMT-treated mice showed significant learning and memory disability. Moreover, TMT increased the level of Siah-1, reduced the expression of SYP in hippocampus and cortex. After 7 days of continuous pretreatment with HRW, the mice showed better memory ability, the expression of Siah-1 and tin content decreased accompanied with the increase of SYP. Conclusions: These results showed that HRW ameliorated the decrease of SYP and the nerve impairment induced by TMT, reduced tin content and up-regulated the expressions of Siah-1, and it might be an important role in the protection of neurodegenerative diseases induced by TMT.