Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappa B activation in a rat model of amyloid-beta-induced Alzheimer’s disease
Read more:
DOI:
10.1016/j.neulet.2011.01.022
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
This study is to examine if hydrogen-rich saline reduced amyloid-beta (A beta) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-kappa B. Sprague-Dawley male rats (n = 18,280-330 g) were divided into three groups, sham operated, A beta 1-42 injected and A beta 1-42 plus hydrogen-rich saline treated animals. Hydrogen-rich saline (5 ml/kg, i.p., daily) was injected for 10 days after intraventricular injection of A beta 1-42. The levels of IL-1 beta were assessed by ELISA analysis, 8-OH-dG by immunohistochemistry in the brain slides, and JNK and NF-kappa B by immunohistochemistry and western blotting. After A beta 1-42 injection, the level of IL-1 beta, 8-OH-dG, JNK and NF-kappa B all increased in brain tissues, while hydrogen-rich saline treatment decreased the level of IL-1 beta, 8-OH-dG and the activation of INK and NF-kappa B. In conclusion, hydrogen-rich saline prevented A beta-induced neuroinflammation and oxidative stress, possibly by attenuatation of activation of c-Jun NH(2)-terminal kinase (JNK) and nuclear factor-kappa B (NF-kappa B) in this rat model. (C) 2011 Elsevier Ireland Ltd. All rights reserved.| Publish Year | 2011 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Neuroscience Letters |
| Primary Topic | Brain |
| Secondary Topic | Alzheimer's Disease |
| Model | Rat |
| Tertiary Topic | Amyloid Beta Toxicity |
| Vehicle | Saline (Dissolved) |
| pH | Neutral |
| Application | Injection |
| Comparison | |
| Complement |