Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats
Read more:
DOI:
10.1016/j.neulet.2017.01.020
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Background: Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest.
Methods: The rats were randomly divided into three groups, sham group (n=30), ischemia/reperfusion group (n=40) and hydrogen-rich saline group (n=40). The rats in experimental groups were subjected to 4minutes of cardiac arrest and followed by resuscitation. Then they were randomized to receive 5ml/kg of either hydrogen-rich saline or normal saline.
Results: Hydrogen-rich saline significantly improves survival rate and neurological function. The beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP). Conclusions: Hydrogen-rich saline attenuates brain I/R injury may through inhibiting hippocampus ERS after cardiac arrest in rats.
| Publish Year | 2017 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Neuroscience Letters |
| Primary Topic | Brain |
| Secondary Topic | Cardiopulmonary Resuscitation (CPR) |
| Model | Rat |
| Tertiary Topic | Hypoxia-Ischemia |
| Vehicle | Saline (Dissolved) |
| pH | Neutral |
| Application | Injection |
| Comparison | |
| Complement |