Hydrogen-Rich Saline May Reduce Kidney Damage in Rats with Severe Pancreatitis
Hydrogen‐Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate‐Induced Severe Acute Pancreatitis by Inhibiting ROS and NF‐ <i>κ</i> B Pathway
Research hubs: Digestive System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Qiao Shi, Kang-Shu Liao, Kai-Liang Zhao, Wei-Xing Wang, Teng Zuo, Wen-Hong Deng, Chen Chen, Jia Yu, Wen-Yi Guo, Xiao-Bo He, Ablikim Abliz, Peng Wang, Liang Zhao
- Journal
- Mediators of Inflammation
- Year
- 2015
- PMID
- 25878401
- Study Type
- Rat
- Delivery
- Saline (Dissolved)
- Dose
- 6 mL/kg intravenously and 20 mL/kg subcutaneously
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 49 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Hydrogen-rich saline may help protect the kidneys from damage during severe acute pancreatitis by reducing inflammation and oxidative stress.
Key Finding
Hydrogen-rich saline reduced kidney damage and inflammatory markers in rats with severe pancreatitis by neutralizing harmful molecules called reactive oxygen species and blocking a key inflammatory pathway in cells.
Summary
This rat study tested whether hydrogen-rich saline (a salt solution containing dissolved hydrogen gas) could protect the kidneys during severe pancreatitis (inflammation of the pancreas). Researchers gave rats either hydrogen-rich saline or regular saline after inducing pancreatitis, then measured kidney damage and inflammatory markers. Hydrogen-rich saline reduced kidney injury markers, decreased harmful inflammatory chemicals, and boosted the body's natural antioxidant defenses compared to regular saline.
Practical Takeaway
This is early-stage research in animals only, so it cannot yet predict effects in humans. While the results suggest hydrogen-rich saline may have protective potential for kidney complications in severe pancreatitis, clinical trials in humans would be needed before any therapeutic recommendations could be made.
Abstract (excerpt)
Hydrogen (H 2 ), a new antioxidant, was reported to reduce • OH and ONOO − selectively and inhibit certain proinflammatory mediators to product, without disturbing metabolic redox reactions or ROS involved in cell signaling. We herein aim to explore its protective effects on acute renal injury…