Hydrogen Gas May Reduce Throat Damage from Breathing Tubes During Surgery
Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression
Research hubs: Respiratory System
- Authors
- Guo Mu, Shuai Chen, Xinyu Chen, Qiang Li, Bin Lu, Xuan Yu
- Journal
- Free Radical Biology and Medicine
- Year
- 2024
- PMID
- 39216558
- Study Type
- Human
- Delivery
- Gas
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 6 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Breathing in hydrogen gas can protect the throat from damage caused by the cuff of a breathing tube during surgery.
Key Finding
Hydrogen inhalation reduced airway damage from breathing tube compression by blocking a cellular death pathway and lowering harmful reactive oxygen species, and hydrogen-enriched saline in the tube cuff reduced postoperative sore throat in surgical patients.
Summary
When a breathing tube is inserted during surgery, the inflatable cuff around the tube can compress and damage the airway lining. This study found that this damage occurs through a process called oxidative stress (harmful chemical reactions) that triggers cell death. Researchers discovered that hydrogen gas inhalation reduced these harmful chemical reactions and prevented cell death by blocking a specific cellular pathway (NLRP3-GSDMD). In patients undergoing surgery, using hydrogen-enriched saline to inflate the breathing tube cuff reduced sore throat after the procedure.
Practical Takeaway
This early evidence suggests hydrogen may help protect the airway during intubation procedures, particularly for reducing postoperative sore throat. However, the study's sample size and duration were not reported, making it difficult to assess the strength of these findings. More research with larger patient groups and longer follow-up is needed before hydrogen can be recommended as a standard protective strategy.
Abstract (excerpt)
The cuff of endotracheal tube (ETT) is an indispensable device for establishing an artificial airway, yet cuff-induced compression often causes damage to the airway mucosa. The mechanism of this damage involves mucosal compression ischemia and the oxidative stress injury following reperfusion…