Hydrogen Water Reduced Inflammation in Colitis in Mice
Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate
Research hubs: Digestive System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (mouse)
- Authors
- Mikihito Kajiya, Marcelo J.B. Silva, Kimihiro Sato, Kazuhisa Ouhara, Toshihisa Kawai
- Journal
- Biochemical and Biophysical Research Communications
- Year
- 2009
- PMID
- 19486890
- Study Type
- Mouse
- Delivery
- Water (Dissolved)
- Dose
- H2-containing water ad libitum for 7 days
- Duration
- 1 weeks
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- United States
TL;DR
Hydrogen gas in drinking water reduced inflammation and damage in a mouse model of human bowel disease.
Key Finding
Molecular hydrogen gas significantly reduced colon inflammation, tissue damage, and inflammatory markers in mice with DSS-induced colitis, suggesting it may have anti-inflammatory effects in inflammatory bowel disease.
Summary
Researchers gave mice a chemical called dextran sodium sulfate (DSS) to create a condition similar to inflammatory bowel disease in humans. Some mice received regular water with DSS, while others received water containing both DSS and molecular hydrogen gas (H2). Over 7 days, mice that received hydrogen gas showed less weight loss, less colon damage, and lower levels of inflammatory markers (immune signaling molecules) compared to mice that only received DSS.
Practical Takeaway
This is an early-stage animal study showing hydrogen water may help reduce colon inflammation in a mouse model of inflammatory bowel disease. However, results in mice do not automatically translate to humans, and much more research—including human trials—would be needed before any health recommendations could be made.
Abstract (excerpt)
By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1)…