Hydrogen and Bone-Destroying Cells in Lab Tests
Hydrogen inhibits the osteoclastogenesis of mouse bone marrow mononuclear cells
Research hubs: Musculoskeletal System
This research was done on cells or tissue in a lab, not in people or animals.
- Evidence type
- Laboratory study (cells or tissue)
- Authors
- Yong Liu, De-Li Wang, Yong-Can Huang, Tian-Bing Wang, Hui Zeng
- Journal
- Materials Science and Engineering C
- Year
- 2020
- PMID
- 32204074
- Study Type
- Cell Culture
- Delivery
- Gas
- Dose
- Five H2 concentrations tested over 5, 7, and 10 days
- H₂ concentration
- 0%, 2%, 25%, 50%, 75%
- Duration
- 10 days
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 22 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Hydrogen gas, a byproduct of magnesium alloy implants, can significantly reduce the formation and activity of bone-resorbing cells, potentially aiding in the healing of bone fractures.
Key Finding
Hydrogen gas at 50-75% concentration significantly inhibited the formation and function of osteoclasts (bone-resorbing cells) in laboratory-cultured mouse bone marrow cells.
Summary
Researchers studied how hydrogen gas affects bone cells in a laboratory setting, specifically cells that break down bone (called osteoclasts). They exposed mouse bone marrow cells to different amounts of hydrogen gas for varying lengths of time and measured how many osteoclasts formed and how active they were. They found that higher concentrations of hydrogen gas (50-75%) reduced the formation of these bone-breaking cells, slowed their growth, and triggered their death.
Practical Takeaway
This is an early-stage laboratory study in mouse cells, not humans, so it cannot yet inform practical health decisions. The findings suggest hydrogen gas may theoretically help prevent excessive bone breakdown, but much more research—including animal studies and eventually human trials—would be needed before any therapeutic application. The study's relevance to hydrogen water consumption is unclear, as the research used direct hydrogen gas exposure rather than dissolved hydrogen in water.
Abstract (excerpt)
Hydrogen (H2) is one of the major biodegradation products of magnesium (Mg) alloys implanted for bony fracture healing and reconstruction; H2 thus plays a significant role in the regulation of local microenvironment and the biology of resident cells. The interactions between the H2 and the local…