Hydrogen Gas Helps Boy Wake Up from Coma After Brain Bleeding
- Authors
- Yan Huang, Feng-Ming Xiao, Wen-Jie Tang, Jing Qiao, Hai-Feng Wei, Yuan-Yun Xie, You-Zhen Wei
- Journal
- World Journal of Clinical Cases
- Year
- 2022
- DOI
- 10.12998/wjcc.v10.i4.1311
- Study Type
- Human
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Persistent Vegetative State
- Body System
- Neurological
TL;DR
An 11-year-old boy in a persistent vegetative state showed remarkable recovery after treatment with high-concentration hydrogen gas.
Key Finding
A single pediatric patient in persistent vegetative state showed dramatic neurological recovery—including restored consciousness, speech, and motor function—after receiving daily high-concentration hydrogen gas inhalation therapy.
Summary
This report describes a single 11-year-old boy who was in a persistent vegetative state (a condition of unconsciousness with minimal awareness) following severe brain bleeding. After standard treatments failed to help over two months, he received daily inhalation of high-concentration hydrogen gas mixed with oxygen for several hours per day. His consciousness, speech, facial expressions, and ability to move improved significantly, and brain imaging showed stabilization of the damaged area.
Practical Takeaway
While this case report is intriguing, it describes only one patient and lacks the controlled comparison needed to prove hydrogen gas caused the improvement. Brain injuries can sometimes improve spontaneously, and other factors may have contributed. Much larger, carefully controlled studies are needed before hydrogen inhalation can be considered an established treatment for this condition.
Abstract
Background: Persistent vegetative state (PVS) is a devastating and long-lasting clinical condition with high morbidity and mortality; currently, there are no available effective interventions. Case summary: We report the case of an 11-year-old boy with PVS caused by severe intracerebral bleeding in the left hemisphere following anticoagulation treatment. The patient's PVS severity showed no notable improvement after 2-mo neuroprotective treatment and rehabilitation, including nerve growth factor and baclofen, hyperbaric oxygen, and comprehensive bedside rehabilitation therapies. Daily inhalation treatment (4-6 h) of high-concentration hydrogen (H2) gas (66.6% H2 + 33.3% O2) was provided. Surprisingly, the patient's orientation, consciousness, ability to speak, facial expressions, and locomotor function were significantly restored, along with improvements in essential general health status, after H2 gas inhalation treatment, which was consistent with stabilized neuropathology in the left hemisphere and increased Hounsfield unit values of computed tomography in the right hemisphere. The patient finally recovered to a near normal conscious state with a Coma Recovery Scale-Revised Score of 22 from his previous score of 3. Conclusion: Phase 1 clinical trials are needed to explore the safety and efficacy of H2 gas inhalation in patients with PVS.