Hydrogen Gas Protects Liver During Life-Threatening Sepsis in Mice
Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (mouse)
- Authors
- Mengying Yan, Yang Yu, Xing Mao, Jingcheng Feng, Yanyan Wang, Hongguang Chen, Keliang Xie, Yong-Hao Yu
- Journal
- International Immunopharmacology
- Year
- 2019
- PMID
- 30877875
- Study Type
- Mouse
- Delivery
- Gas
- Dose
- 2% H2 gas inhalation for 3 hours starting at 1 hour after surgery
- H₂ concentration
- 2% H2 gas
- Duration
- 1 weeks
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 63 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Inhaling hydrogen gas can help mice recover from liver damage caused by sepsis by affecting a specific cellular cleanup process.
Key Finding
Hydrogen gas inhalation (2% for 3 hours) improved survival rates and reduced liver damage markers in septic mice, with the protective effect dependent on a specific cellular pathway called FUNDC1-mediated mitophagy.
Summary
Researchers studied whether hydrogen gas could protect the liver during sepsis (a severe infection) in mice. They found that mice breathing 2% hydrogen gas for 3 hours after sepsis showed better survival rates, less liver damage, and improved liver function compared to untreated mice. The protective effect appeared to work through a cellular cleanup process called mitophagy (where cells remove damaged mitochondria, which are the energy-producing parts of cells).
Practical Takeaway
This early evidence from animal studies suggests hydrogen gas inhalation may help protect the liver during severe infections, but this is preliminary research in mice only. Human studies would be needed to determine if these results apply to people with sepsis. The specific mechanism identified (FUNDC1-dependent mitophagy) may be important for understanding how hydrogen could work therapeutically, but more research is required before any clinical applications.
Abstract (excerpt)
Sepsis-induced hepatic dysfunction is considered as an independent risk factor of multiple organ dysfunction syndrome (MODS) and death. Mitophagy, a selective form of autophagy, plays a major role in sepsis-induced organ damage. We have demonstrated that hydrogen gas (H2), a selective antioxidant…