Hydrogen Water Protects Skin Cells from Arsenic Damage
- Authors
- Wei-Tai Yu, Yi-Ching Chiu, Chih-Hung Lee, Tohru Yoshioka, Hsin-Su Yu
- Journal
- Journal of Asian Earth Sciences
- Year
- 2013
- DOI
- 10.1016/j.jseaes.2013.07.007
- Study Type
- Cell Culture
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Taiwan
- Health Condition
- Arsenic Poisoning
- Body System
- Integumentary
TL;DR
Drinking water contaminated with arsenic can disrupt important cell processes in the skin, but hydrogen-enriched water might help counteract these effects.
Key Finding
Arsenic impairs calcium signaling in skin cells primarily through oxidative stress, and hydrogen-enriched water partially restored this impaired calcium signaling in laboratory conditions.
Summary
This laboratory study examined how arsenic damages skin cells by disrupting calcium signaling (a process cells use to communicate and function properly), and whether hydrogen-enriched water could reverse this damage. Researchers exposed skin cells to arsenic and found it increased harmful molecules called reactive oxygen species (ROS), which blocked normal calcium movement. When they pretreated cells with hydrogen-enriched water before adding arsenic, the water partially restored calcium signaling, suggesting hydrogen's antioxidant properties may counteract arsenic's damaging effects.
Practical Takeaway
This is an early-stage cell culture study, not human research, so it cannot yet support health claims about hydrogen water for arsenic exposure or skin disease prevention. The findings suggest hydrogen water's antioxidant properties may theoretically help protect against arsenic damage, but much more research—including animal and human studies—would be needed before any practical recommendations could be made.
Abstract
Endemic contamination of artesian water for drinking by arsenic is known to cause several human cancers, including cancers of the skin, bladder, and lungs. In skin, multiple arsenic-induced Bowen's disease (As-BD) can develop into invasive cancers after decades of arsenic exposure. The characteristic histological features of As-BD include full-layer epidermal dysplasia, apoptosis, and abnormal proliferation. Calcium propagation is an essential cellular event contributing to keratinocyte differentiation, proliferation, and apoptosis, all of which occur in As-BD. This study investigated how arsenic interferes calcium propagation of skin keratinocytes through ROS production and whether hydrogen-enriched water would restore arsenic-impaired calcium propagation. Arsenic was found to induce oxidative stress and inhibit ATP- and thapsigaragin-induced calcium propagation. Pretreatment of arsenic-treated keratinocytes by hydrogen-enriched water or beta-mercaptoethanol with potent anti-oxidative effects partially restored the propagation of calcium by ATP and by thapsigaragin. It was concluded that arsenic may impair calcium propagation, likely through oxidative stress and interactions with thiol groups in membrane proteins.