Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats

Jing Yang, Jingjing Cai, Liqun Zhu, Lu Fu, Rui Luan, Shujing Wu, Yanli Dong, Zhixin Fan

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DOI: 10.1691/ph.2014.3859 DOI is the universal ID for this study.

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Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.

Publish Year 2014
Country China
Rank Positive
Journal Pharmazie
Primary Topic Heart
Secondary TopicCancer
Model Rat
Tertiary TopicChemotherapy Toxicity (Doxorubicin)
Vehicle Saline (Dissolved)
pH Neutral
Application Injection