Hydrogen Reduced Allergic Inflammation in Mice

Hydrogen gas treatment reduces airway inflammation by fixing an imbalance in the way cells produce energy.

Allergic airway inflammation in asthma is associated with a shift in how cells produce energy, and hydrogen treatment reversed this shift and reduced inflammation in mice.

This study examined how molecular hydrogen might reduce allergic airway inflammation (as seen in asthma) by affecting how cells produce energy. Researchers compared cells and lungs from asthmatic mice and asthmatic patients to healthy controls, finding that asthmatic inflammation was linked to a shift in how cells generate energy—moving away from the efficient mitochondrial system (the cell's power plant) toward a less efficient glucose-burning process. When researchers treated asthmatic mice with hydrogen dissolved in saline, the energy production shifted back to normal, and airway inflammation decreased.

This is an early-stage mouse study that suggests hydrogen may help manage allergic airway inflammation by restoring normal cellular energy production. However, this research has not been tested in humans, and the study duration and sample size were not reported, so it is too early to draw conclusions about whether hydrogen water would have similar effects in people with asthma or allergies.

Abstract Mechanisms mediating the protective effects of molecular hydrogen (H 2 ) are not well understood. This study explored the possibility that H 2 exerts its anti-inflammatory effect by modulating energy metabolic pathway switch. Activities of glycolytic and mitochondrial oxidative…

Read the full abstract on PubMed