Hydrogen Gas Reduced Organ Injury in Sepsis in Mice
Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research
Research hubs: Respiratory System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (mouse)
- Authors
- Hong-Guang Chen, Huan-Zhi Han, Yuan Li, Yong-Hao Yu, Ke-Liang Xie
- Journal
- International Immunopharmacology
- Year
- 2019
- PMID
- 31830624
- Study Type
- Mouse
- Delivery
- Saline (Dissolved)
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 57 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Hydrogen treatment can help protect against organ damage in sepsis by reducing cell stress and enhancing the cell's cleanup processes.
Key Finding
In mice with sepsis, hydrogen gas reduced organ injury and improved organ function by activating the cell's cleanup system (autophagy) and reducing cellular stress in the endoplasmic reticulum.
Summary
This study used mice with sepsis (a severe infection causing organ damage) to investigate how hydrogen gas might protect organs. Researchers found that sepsis triggers two harmful cellular processes: endoplasmic reticulum stress (a type of cellular damage) and impaired autophagy (the cell's cleanup system). When hydrogen was given to septic mice, it reduced endoplasmic reticulum stress, improved autophagy function, and decreased inflammation and organ damage in the lungs, liver, and kidneys.
Practical Takeaway
This is early laboratory research in mice only, not humans. While the findings suggest hydrogen may have protective effects against sepsis-related organ damage through specific cellular mechanisms, much more research—including human studies—would be needed before any therapeutic claims could be made. The results are interesting but cannot yet be applied to human sepsis treatment.
Abstract (excerpt)
Aims: Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Although much progress has been made in understanding the pathophysiology of sepsis, further discussion and study of the detailed therapeutic mechanisms are needed. Autophagy…