Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water

Bunpei Sato, Keiko Abe, Shinji Okada, Shota Ushiama, Soichi Arai, Yuji Nakai

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DOI: 10.1271/bbb.100819 DOI is the universal ID for this study.

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The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.

Publish Year 2014
Country Japan
Rank Positive
Journal Bioscience, Biotechnology, and Biochemistry
Primary Topic Liver
Secondary TopicROS-Scavenging
Model Rat
Tertiary TopicOxidative Stress
Vehicle Water (Dissolved)
pH Neutral
Application Ingestion