Hydrogen Injections Protect Male Fertility from Cigarette Smoke Damage
- Authors
- S Chen, W Jiang, X-H Wang
- Journal
- West Indian Medical Journal
- Year
- 2015
- DOI
- 10.7727/wimj.2015.332
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Male Infertility
- Body System
- Reproductive System
TL;DR
Hydrogen injections may protect male rats' reproductive systems from damage caused by exposure to cigarette smoke.
Key Finding
Hydrogen injections protected rat testicles from cigarette smoke damage by reducing oxidative stress and improving sperm count and quality.
Summary
Researchers tested whether hydrogen could protect rat testicles from damage caused by cigarette smoke exposure. Rats that received hydrogen injections had better sperm quality (more sperm, less deformed sperm), higher levels of protective antioxidant molecules, and lower levels of oxidative damage markers compared to control rats exposed to the same smoke.
Practical Takeaway
This is an early-stage animal study showing hydrogen may help counteract smoking-related reproductive damage, but it involved injected hydrogen in rats—not the oral hydrogen water that consumers use. Much more research, including human studies, would be needed before drawing any conclusions about hydrogen water's effects on human fertility or smoking-related health issues.
Abstract
Smoking is one of the most common reasons inducing reactive oxygen species in semen. High concentration of active oxygen will cause decrease of sperm density and viability and induce oxidative injury of sperm DNA which has become the hot spot in male infertility. Although hydrogen was found to be an effective remover of active oxygen in liver, heart, kidney and brain, the same effect has not been discussed in reproductive system. The aim of this study was to investigate the protective effect of hydrogen against cigarette smoke-induced damage in rat reproductive system. Adult male Wistar rats were randomly divided into four groups to conduct this experiment, results showed that rats in SK+HSI group (passive smoking and hydrogen subcutaneous injection group) exhibited larger amount of sperm count, smaller sperm deformation rate, higher levels of testosterone and SOD in serum and testis, lower levels of MDA in testis and less morphologic abnormalities compared to SK+NSI group (passive smoking and nitrogen subcutaneous injection group). As a consequence, we concluded that injected subcutaneously exerted protective effects on reproductive system injury of male rats exposed to cigarette smoke through inhibiting oxidative damage.