Hydrogen Water Reduces Gum Disease Inflammation in Rats
Effect of electrolyzed reduced water on Wistar rats with chronic periodontitis on malondialdehyde levels
Research hubs: Immune System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Rini Devijanti Ridwan, Wisnu Setyari Juliastuti, R. Darmawan Setijanto
- Journal
- Dental Journal (Majalah Kedokteran Gigi)
- Year
- 2017
- Study Type
- Rat
- Participants
- 40
- Delivery
- Water (Electrolysis)
- Dose
- ERW via drinking water
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 2 (OpenAlex, as of November 2026)
- Country
- Indonesia
TL;DR
Drinking alkaline water with magnesium ions can reduce cell damage in rats with gum disease.
Key Finding
Rats with gum disease that consumed electrolyzed reduced water had significantly lower blood levels of malondialdehyde, a marker of oxidative stress, compared to rats drinking regular water.
Summary
Researchers gave rats with gum disease either regular drinking water or electrolyzed reduced water (ERW), which is alkaline water made through electrolysis that contains magnesium ions. They measured malondialdehyde (MDA), a marker of oxidative stress or cellular damage, in the rats' blood. Rats that drank ERW had significantly lower MDA levels than those drinking regular water, suggesting ERW may help reduce the cellular damage associated with gum disease.
Practical Takeaway
This early animal study suggests ERW may help reduce oxidative stress markers associated with gum disease, but the findings are limited to rats and the study duration and sample details were not reported. Much more research, including human trials, would be needed before drawing conclusions about whether ERW could benefit people with periodontal disease.
Abstract (excerpt)
Background: Periodontal disease is a progressive destructive change that causes loss of bone and periodontal ligaments around the teeth that can eventually lead to its loss. The main bacteria in chronic periodontitis is Porphyromonas gingivalis. Aggregatibacter actinomycetemcomitans, a pathogen…