How Molecular Hydrogen Works in the Body: A Scientific Review
- Authors
- John T. Hancock, Grace Russell
- Journal
- Plants
- Year
- 2021
- DOI
- 10.3390/plants10020367
- Study Type
- clinical
- Peer Reviewed
- Yes
- Country
- United Kingdom
- Health Condition
- Oxidative Stress
- Body System
- Cellular
TL;DR
Scientists found that a gas called molecular hydrogen might help treat diseases and make plants grow better, probably by acting like a cleanup crew that removes harmful stuff from our cells—but they're not totally sure exactly how it works yet.
Key Finding
Molecular hydrogen likely works through antioxidant mechanisms and by neutralizing harmful hydroxyl radicals, but the precise cellular pathways through which it operates remain incompletely understood.
Summary
This article reviews what scientists currently know about how molecular hydrogen (H2) works in cells and organisms. Researchers have suggested that hydrogen might help treat diseases in humans and improve plant growth, possibly by acting as an antioxidant (a substance that protects cells from damage), but the exact mechanisms remain unclear and debated among scientists.
Practical Takeaway
This is a review article summarizing existing knowledge rather than new research, and it emphasizes that while hydrogen shows promise, scientists still don't fully understand how it works at the cellular level. More research is needed before clear health recommendations can be made.
Abstract
Molecular hydrogen (H2) is now considered part of the suite of small molecules that can control cellular activity. As such, H2 has been suggested to be used in the therapy of diseases in humans and in plant science to enhance the growth and productivity of plants. Treatments of plants may involve the creation of hydrogen-rich water (HRW), which can then be applied to the foliage or roots systems of the plants. However, the molecular action of H2 remains elusive. It has been suggested that the presence of H2 may act as an antioxidant or on the antioxidant capacity of cells, perhaps through the scavenging of hydroxyl radicals. H2 may act through influencing heme oxygenase activity or through the interaction with reactive nitrogen species. However, controversy exists around all the mechanisms suggested. Here, the downstream mechanisms in which H2 may be involved are critically reviewed, with a particular emphasis on the H2 mitigation of stress responses. Hopefully, this review will provide insight that may inform future research in this area.