Hydrogen Supplement Reduced Fatty Liver in High-Fat Diet Rats
Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer
Research hubs: Metabolic Syndrome · Digestive System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Chen Hou, Yongyao Wang, Erkang Zhu, Chunhong Yan, Lin Zhao, Xiaojie Wang, Yingfeng Qiu, Hui Shen, Xuejun Sun, Zhihui Feng, Jiankang Liu, Jiangang Long
- Journal
- Biochemical Pharmacology
- Year
- 2016
- PMID
- 26774456
- Study Type
- Rat
- Delivery
- Water (Dissolved)
- Dose
- Coral calcium hydride for 13 weeks
- Duration
- 3 months
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 42 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Coral calcium hydride (CCH), a new type of hydrogen-releasing compound, was shown to reduce fat accumulation in the liver and improve overall metabolism in rats on a high-fat diet.
Key Finding
Coral calcium hydride reduced liver fat accumulation and improved metabolic health in rats with diet-induced fatty liver disease by releasing molecular hydrogen that reduced oxidative stress and improved mitochondrial function.
Summary
Researchers tested a new form of coral calcium that releases molecular hydrogen in the body on rats fed a high-fat diet that causes fatty liver disease. The treatment reduced weight gain, improved blood sugar and fat levels, and decreased fat buildup in the liver. It also reduced harmful molecules (oxidative stress) in liver cells and improved how their energy-producing structures (mitochondria) worked.
Practical Takeaway
This early-stage animal study suggests coral calcium hydride may help prevent fatty liver disease through hydrogen release, but results are limited to rats fed a high-fat diet. Human studies would be needed to determine if these benefits apply to people, and the study does not establish whether this approach is more effective than other interventions.
Abstract (excerpt)
Diet-induced nonalcoholic fatty liver disease (NAFLD) is characterized by profound lipid accumulation and associated with an inflammatory response, oxidative stress and hepatic mitochondrial dysfunction. We previously demonstrated that some mitochondrial nutrients effectively ameliorated high fat…