Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
Read more:
DOI:
10.1016/j.bbrc.2008.10.156
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med. 13 (2007) 688-694]. Here, we investigated whether drinking H(2)-dissolved water at a saturated level (H(2)-water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE(-/-)), a model of the spontaneous development of atherosclerosis. ApoE(-/-) mice drank H(2)-water ad libitum from 2 to 6 month old throughout the whole period. Atherosclerotic lesions were significantly reduced by ad libitum drinking of H(2)-water (p=0.0069) as judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H(2)-dissolved water has the potential to prevent arteriosclerosis.| Publish Year | 2008 |
|---|---|
| Country | Japan |
| Rank | Positive |
| Journal | Biochemical and Biophysical Research Communications |
| Primary Topic | Heart |
| Secondary Topic | Atherosclerosis |
| Model | Mouse |
| Tertiary Topic | Oxidative Stress |
| Vehicle | Water, Commercial (Blue Mercury) |
| pH | Neutral |
| Application | Ingestion |
| Comparison | |
| Complement |