Hydrogen Therapy Reduces Radiation Side Effects in Cervical Cancer
Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
Research hubs: Reproductive System
- Evidence type
- Randomized controlled trial · Human study
- Authors
- Bo Liu, Yao Bao, Jinan Ma, Xiaodong Wang, Yeqian Feng
- Journal
- Advances in Radiation Oncology
- Year
- 2025
- PMID
- 41020280
- Study Type
- Human
- Participants
- 58
- Delivery
- Gas
- Dose
- 3 L/min, 2 h/day on each radiation therapy day
- H₂ concentration
- 66.6% hydrogen, 33.3% oxygen
- Funding
- research project of xinrui tumor suportive therapy (cphcf-2023-035)
- Conflicts of interest
- None declared
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
TL;DR
Inhaling hydrogen gas during cancer treatment reduced gut inflammation and symptoms of radiation enteritis without affecting tumor response.
Key Finding
Cervical cancer patients who inhaled hydrogen gas during concurrent chemoradiation therapy had significantly lower inflammatory markers and milder intestinal damage compared to the control group, while maintaining equivalent cancer treatment effectiveness.
Summary
This study tested whether inhaled hydrogen gas could reduce intestinal damage and inflammation in cervical cancer patients receiving radiation and chemotherapy together. Patients who inhaled a hydrogen-oxygen gas mixture for 2 hours on each radiation day showed lower levels of inflammatory markers (substances in the blood that indicate inflammation) and fewer gastrointestinal symptoms compared to patients who received standard treatment alone, without affecting how well the cancer treatment worked.
Practical Takeaway
This early human study suggests hydrogen inhalation may help reduce radiation-related intestinal side effects in cancer patients, though the relatively small sample size and lack of reported study duration mean larger, longer-term studies are needed to confirm these findings. The results are specific to patients undergoing cancer treatment and cannot be generalized to other populations or health conditions.
Abstract (excerpt)
Purpose: Acute radiation enteritis (ARE) is a common toxic inflammatory reaction in patients with cervical cancer undergoing concurrent chemoradiation therapy (CCRT). Molecular hydrogen, as a novel antioxidant and anti-inflammatory agent, may alleviate treatment-related toxicity. This study aimed…