Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

Emi Yamano, Junzo Nojima, Kanako Tajima, Kei Mizuno, Kyoko Ebisu, Kyosuke Watanabe, Shigeru Kabayama, Yasuyoshi Watanabe, Yusuke Ohsaki

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DOI: 10.1016/j.heliyon.2022.e11853 DOI is the universal ID for this study.

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Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present observational study, we investigated the antioxidant effects of a daily continuous intake of EHW in healthy adults. The concentrations of serum reactive oxygen metabolites-derived compounds (d-ROMs) and blood urea nitrogen in healthy volunteers (n = 64) who had a habit of intake over 500 mL/day of EHW at least 5 days a week for longer than 6 months were lower than those of age- and sex-matched controls (n = 470) without the habit of EHW intake. Oxidation stress index which the ratio between concentrations in d-ROMs and biological antioxidant potential was correlated with the serum concentration of high-sensitivity C-reactive protein or low-density lipoprotein cholesterol in the EHW group. These results suggest that the continuous intake of EHW induces antioxidant effects and may contribute to alleviate the risk of various oxidative stress-related dysfunctions and diseases in healthy adults.

Publish Year 2022
Country Japan
Rank Positive
Journal Heliyon
Primary Topic Whole Body
Secondary TopicHydrogen Biology
Model Human
Tertiary TopicOxidative Stress
Vehicle Water (Electrolysis)
pH Alkaline
Application Ingestion