Hydrogen Water Reduces Oxidative Stress in Healthy Adults
Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults
Research hubs: Oxidative Stress · Cardiovascular System
- Evidence type
- Observational study · Human study
- Authors
- Kei Mizuno, Kyosuke Watanabe, Emi Yamano, Kyoko Ebisu, Kanako Tajima, Junzo Nojima, Yusuke Ohsaki, Shigeru Kabayama, Yasuyoshi Watanabe
- Journal
- Heliyon
- Year
- 2022
- PMID
- 36468139
- Study Type
- Human
- Participants
- 534
- Delivery
- Water (Electrolysis)
- Dose
- >500 mL/day of electrolyzed hydrogen water at least 5 days a week for longer than 6 months
- H₂ concentration
- 100 to 1,300 ppb
- Duration
- 6 months
- Funding
- Nihon Trim Co., Ltd (2022-0250); RIKEN Compass to Healthy Life Research Complex Program (RC-01) of the Japan Science and Technology Agency (JST)
- Conflicts of interest
- Y.W. received funding from Nihon Trim Co., Ltd. S.K. is an employee of Trim Medical Institute Co. Ltd. and head of research group.
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 8 (OpenAlex, as of November 2026)
- Country
- Japan
TL;DR
Drinking electrolyzed hydrogen water (EHW) every day may help reduce harmful oxidative stress in healthy adults, potentially lowering the risk of various diseases.
Key Finding
People who regularly drank electrolyzed hydrogen water had significantly lower levels of oxidative stress markers compared to those who didn't drink it.
Summary
This study looked at whether drinking electrolyzed hydrogen water (water treated with electricity to add hydrogen) every day could reduce oxidative stress in healthy people. Researchers compared 64 people who drank more than 500 mL of this water at least 5 days a week for at least 6 months to 470 people who didn't drink it. They found that the hydrogen water drinkers had lower levels of harmful oxidative compounds (molecules that damage cells) and better antioxidant markers than the control group.
Practical Takeaway
This observational study suggests that daily hydrogen water consumption may support antioxidant activity in healthy adults, though the study design (comparing existing habits rather than randomly assigning people to drink it) limits how strongly we can conclude this. The findings are preliminary and would benefit from larger, controlled trials to confirm whether hydrogen water actually causes these changes or if other factors explain the differences between groups.
Abstract (excerpt)
Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present…