Hydrogen Water Reduces Intestinal Damage and Blood Clotting Issues in Rats
Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-<i>κ</i>B/NLRP3 Pathway
Research hubs: Digestive System · Cardiovascular System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Ling Yang, Yan Guo, Xin Fan, Ye Chen, Bo Yang, Ke-Xuan Liu, Jun Zhou
- Journal
- Mediators of Inflammation
- Year
- 2020
- PMID
- 32587471
- Study Type
- Rat
- Delivery
- Saline (Dissolved)
- Dose
- 10 or 20 mL/kg hydrogen-rich solution intravenously injected at 10 min before reperfusion
- Duration
- 1 day or less
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 27 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Hydrogen-rich solution (HRS) treatment improves survival and reduces blood clotting issues and inflammation in rats with intestinal damage due to restricted and then restored blood flow.
Key Finding
Hydrogen-rich solution improved survival rates and reduced intestinal damage, inflammation, and coagulation disorders in rats with intestinal ischemia/reperfusion injury.
Summary
This rat study tested whether hydrogen-rich solution could help reduce damage from intestinal ischemia/reperfusion injury—a condition where blood flow to the intestines is blocked and then restored, causing inflammation and blood clotting problems. Researchers gave rats either hydrogen-rich solution or regular saline before allowing blood flow to return to their intestines. Rats receiving hydrogen-rich solution had better survival rates, less intestinal damage, and reduced inflammation and blood clotting abnormalities compared to the control group.
Practical Takeaway
This early animal study suggests hydrogen water may help protect against intestinal damage from lack of blood flow, but these results are from rats only and have not been tested in humans. Much more research, including human trials, would be needed before any conclusions could be drawn about hydrogen water's effects in people with similar conditions.
Abstract (excerpt)
Intestinal ischemia/reperfusion (I/R) injury often causes inflammatory responses and coagulation disorders, which is further promoting the deterioration of the disease. Hydrogen has anti-inflammatory, antioxidative, and antiapoptotic properties against various diseases. However, the effect…