Hydrogen Water Lowers Bad Cholesterol and Boosts Heart Health
- Authors
- Chuanlong Zong, Guohua Song, Shutong Yao, Luqin Li, Yang Yu, Lei Feng, Shoudong Guo, Tian Luo, Shu-Cun Qin
- Journal
- Metabolism
- Year
- 2012
- DOI
- 10.1016/j.metabol.2011.10.014
- Study Type
- Hamster
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- High Cholesterol
- Body System
- Cardiovascular
TL;DR
Injecting hydrogen-saturated saline into hamsters on a high-fat diet lowered their bad cholesterol levels and improved the health and function of their good cholesterol.
Key Finding
Hydrogen-saturated saline injections reduced LDL cholesterol levels and improved HDL function in hamsters fed a high-fat diet.
Summary
Researchers gave hamsters on a high-fat diet injections of hydrogen-saturated saline (salt water containing dissolved hydrogen gas) for 4 weeks. They found that this treatment lowered the hamsters' LDL cholesterol (often called "bad" cholesterol) and improved the function of HDL cholesterol (often called "good" cholesterol). The HDL became better at removing excess cholesterol from cells and protecting against cholesterol oxidation (a process that damages cholesterol in the bloodstream).
Practical Takeaway
This is an early-stage animal study in hamsters, not humans, so results cannot be directly applied to people. While the findings suggest hydrogen may have potential benefits for cholesterol levels and heart health, much more research—including human trials—would be needed before drawing any conclusions about hydrogen water's effects on human health.
Abstract
Hydrogen (dihydrogen; H(2)) has an antiatherosclerotic effect in apolipoprotein (apo) E knockout mice. The goals of this study were to further characterize the effects of H(2) on the content, composition, and biological activities of plasma lipoproteins in golden hamsters. Plasma analysis by enzymatic method and fast protein liquid chromatography showed that 4-week intraperitoneal injection of hydrogen-saturated saline remarkably decreased plasma total cholesterol and low-density lipoprotein (LDL) cholesterol levels in high-fat diet-fed hamsters. Sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis of apolipoproteins from ultracentrifugally isolated plasma lipoproteins revealed a marked decrease of apo B100 and apo B48 in LDL. A profound decrease of apo E level in very low-density lipoprotein was also observed. Besides, we determined the functional quality of high-density lipoprotein (HDL) particles isolated from H(2)-treated and control mice. H(2) significantly improved HDL functionality assessed in 2 independent ways, namely, (1) stimulation of cholesterol efflux from macrophage foam cells by measuring HDL-induced [(3)H]cholesterol efflux and (2) protection against LDL oxidation as a measure of Cu(2+)-induced thiobarbituric acid reactive substances formation. Administration of hydrogen-saturated saline decreases plasma LDL cholesterol and apo B levels and improves hyperlipidemia-injured HDL functions, including the capacity of enhancing cellular cholesterol efflux and playing antioxidative properties, in high-fat diet-fed hamsters.