Hydrogen Therapy Was Linked to Reduced Mouth Ulcers in One Patient
Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report
Research hubs: Immune System
- Evidence type
- Case report or series · Human study
- Authors
- Che-Cheng Lin, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Kuang-Yih Wang, Feng-Cheng Liu
- Journal
- In Vivo
- Year
- 2026
- PMID
- 41760342
- Study Type
- Human
- Participants
- 1
- Delivery
- Gas (Sustained Release)
- Dose
- oral molecular hydrogen capsules
- Duration
- 18 months
- Funding
- National Science and Technology Council, Taiwan (NSTC 112-2314-B-016-033); National Science and Technology Council, Taiwan (NSTC 113-2314-B-016-052); National Science and Technology Council, Taiwan (NSTC 114-2314-B-016-052-MY3); National Science and Technology Council, Taiwan (NSTC 114-2313-B-019-012); Tri-Service General Hospital, Taiwan (TSGH-E-112218); Tri-Service General Hospital, Taiwan (TSGH-E-113238)
- Conflicts of interest
- None declared
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 0 (OpenAlex, as of November 2026)
- Country
- Taiwan
TL;DR
In a single case, adjunctive molecular hydrogen therapy improved refractory oral ulcers and showed immunomodulatory effects in a patient with Behçet’s disease and Sjögren’s syndrome.
Key Finding
In this single patient case, adding molecular hydrogen capsules to standard treatment was associated with marked improvement in refractory oral ulcers, reduced anti-Ro antibody levels, and favorable changes in T cell markers over several months.
Summary
A 67-year-old woman with two autoimmune diseases (Behçet's disease and Sjögren's syndrome) that caused painful mouth ulcers despite standard treatments was given molecular hydrogen capsules as an additional therapy. Over several months, her mouth ulcers improved significantly, her bleeding decreased, and blood tests showed reduced levels of a problematic antibody and changes in immune cells that suggest the hydrogen may have helped regulate her immune system.
Practical Takeaway
This is a single case report of one patient, not a controlled study, so it provides only preliminary evidence that hydrogen may help with these specific autoimmune conditions. Anyone with Behçet's disease or Sjögren's syndrome considering hydrogen therapy should discuss it with their rheumatologist, as much larger and more rigorous studies are needed to confirm whether hydrogen actually causes these improvements or if other factors were responsible.
Abstract (excerpt)
Background/aim Behçet's Disease is a systemic vasculitis affecting both venous and arterial vessels, characterized by painful oral and genital ulcers. Primary Sjögren's Syndrome is an autoimmune disorder mainly targeting exocrine glands, especially the salivary and lacrimal glands, with possible…