A green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry

Bo Wang, Guohua Qi, Haijuan Li, Xiangfu Song, Yongdong Jin

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DOI: 10.1093/nsr/nwz199 DOI is the universal ID for this study.

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By combined use of traditional Chinese acupuncture Fe needle electrode and in-vivo electrochemistry, we achieve in-vivo H2 generation in tumors in a controllable manner and exploited it for effective and green therapy of tumor for the first time. The cathodic acupuncture electrodes working under the applied voltage of ~ 3 volt (with minimal damage to the living body) undergo effectively electrochemical reactions in the acidic tumor area to produce sufficient H2 locally, causing cancer cells to burst and die. Due to puncture positioning, acidic tumor microenvironment and gas diffusion effect, the developed H2 generation electrochemotherapy (H2-ECT) strategy enables precise and large-scale tumor therapy, as demonstrated by in vivo treatment of diseased mice (glioma and breast cancers). Such green H2-ECT is simple, highly efficient and minimally invasive, requiring no expensive medical equipment or (nano)materials and medication, and is therefore very promising for potential clinic applications.

Publish Year 2019
Country China
Rank Positive
Journal National Science Review
Primary Topic Whole Body
Secondary TopicCancer
Model Mouse
Tertiary TopicNovel Therapy
Vehicle Gas
pH N/A
Application In Vivo Biotic Production
Complement Acupuncture