All Studies

Rectal insufflation of hydrogen gas: An infallible test in the diagnosis of visceral injury of the gastro-intestinal canal in penetrating wounds of the abdomen

An Essay on the Medicinal Properties of Factitious Airs: With an Appendix, on the Nature of Blood

Researches, Chemical and Philosophical; Chiefly Concerning Nitrous Oxide, or Dephlogisticated Nitrous Air, and Its Respiration

Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas

A Letter to Erasmus Darwin, M.D. on a New Method of Treating Pulmonary Consumption, and Some Other Diseases Hitherto Found Incurable

Phase-Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar-Reduced Regeneration of Burn Wounds

Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical challenge, demanding therapeutics capable of coordinated infection control, inflammation modulation, and tissue regeneration. Here, we report a phase-programmed microneedle (MN) patch (QR/AB-MNs) that…

Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications

Complex bone defects remain major clinical challenges due to their multifaceted pathological microenvironment. In recent years, hydrogen (H2) therapy has emerged as a rapidly developing strategy for bone repair, leveraging its redox-regulatory and other microenvironment-modulating effects. However…

Hydrogen: a review of the effects and underlying mechanisms in oral diseases

Oral diseases can affect the quality of life of patients and cause secondary systemic diseases, thereby harming systemic health. Hydrogen has been shown to exhibit anti-oxidant stress, anti-inflammatory and anti-apoptosis and other effects, indicating its therapeutic significance for many kinds…

Generation and Application of Ultra-Fine, Long-Term Stable Nanobubble Water: An Evaluation of Inclusion Effects on Aromatic Components and Antimicrobial Activity

Nano- and pico-bubble water (NPB), containing hydrogen or ozone, is widely used as a cleaning agent due to its bactericidal and antiviral properties. However, some products-such as certain hydrogen waters-contain only large bubbles or have an extremely low bubble count, making them sometimes…

Research Progress of Molecular H2 in Mediating Immune Tolerance via Regulating Tregs-from the Perspective of the 2025 Nobel Prize in Physiology or Medicine

The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi in recognition of their pioneering contributions to the field of regulatory T cells (Tregs) and peripheral immune tolerance-defining Tregs as the core regulatory subset maintaining…

Paradigm shift in hydrogen medicine: Target molecules and catalytic mechanisms elucidated at the atomic level

Molecular hydrogen (H2) has been shown to exert antioxidant and anti-inflammatory effects across a broad spectrum of disease models and clinical trials; however, its direct reaction rate with hydroxyl radicals (•OH) in aqueous solution is exceedingly slow, and the underlying mechanism of action has…

Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage

Background: Intracerebral hemorrhage (ICH) is a devastating stroke subtype with high mortality and disability, primarily driven by secondary brain injury involving oxidative stress, neuroinflammation, and apoptosis. Molecular hydrogen (H₂) exhibits potent neuroprotective effects; however…

Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy

Autophagy is an intracellular recycling system that contributes to the maintenance of cellular homeostasis. However, by providing tolerance to various stressors, autophagy promotes the survival and proliferation of cancer cells and confers resistance to chemotherapy. Anticancer drugs activate…

Bioinspired Integrated MgH2 Hydrogel Synergistically Modulates the Osteo-Immune Microenvironment for Enhanced Bone Repair

Magnesium-based biomaterials show great potential in bone regeneration due to their inherent biocompatibility, osteogenic activity, and ability to modulate the immune microenvironment. However, their rapid degradation rate remains a critical barrier to clinical translation. To address these…

Molecular hydrogen as a redox-active regulator of toxic chemical foodborne hazards: Delivery technologies and matrix-dependent mechanisms

Toxic chemical hazards in food systems, including biogenic amines (BAs), nitrites, and heavy metals, pose persistent risks due to their formation, transformation, accumulation, bioaccessibility, and toxicity, which are influenced by redox imbalance, microbial metabolism, and matrix-dependent…

Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy

Glaucoma-induced optic nerve damage is known to be a leading cause of blindness worldwide, yet current therapies mainly focus on reducing intraocular pressure without paying significant attention to the oxidative stress and inflammation in ocular tissues. Here, we address this issue by developing…

The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?

Background: The human gut microbiome plays many essential roles, but an often-overlooked role is to maintain an abundant supply of deuterium depleted (deupleted) nutrients to fuel the host mitochondria. Excess deuterium (heavy hydrogen) damages mitochondrial ATP synthase nanomotors, leading…

Respiratory-physiology modeling of therapeutic hydrogen inhalation: defining the fraction of inspired hydrogen (FiH2) and flow-rate requirements

Background: Molecular hydrogen (H2 gas) has emerged as a promising therapeutic agent with reported benefits across oxidative stress, inflammation, cardiovascular, and neurodegenerative conditions. Among administration routes, inhalation provides direct systemic delivery but has been hindered…

IBS and SIBO: Gut Microbiota, Pathophysiology, and Non-Pharmacological Interventions

Irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) share symptoms such as abdominal pain, bloating, and altered bowel habits. Both are linked to dysbiosis and gut-brain axis dysfunction. IBS is a multifactorial disorder characterized by abnormal motility, visceral…

Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Current treatments mainly involve drugs and surgery, but face limitations like adverse effects, invasive complications, and poor outcomes. Emerging nanomaterial-mediated modalities, particularly photothermal therapy (PTT)…