All Studies

Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and <scp>N</scp>‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats

AimIn cirrhosis, increased oxidative stress leads to systemic and splanchnic hyperdynamic circulation, splanchnic angiogenesis, portosystemic collateral formation, hepatic endothelial dysfunction, increased intrahepatic resistance and the subsequent portal hypertension. Like N‐acetylcysteine…

Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study

The aim of this study was to demonstrate the safety and efficacy of H2-saline infusion for treatment of rheumatoid arthritis (RA). We conducted a randomized, double-blind, placebo-controlled investigation of the infusion of 1 ppm H2-dissolved saline (H2-saline) in 24 RA patients. Patients were…

A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine

Hydrogen is the most abundant chemical element in the Universe, but is seldom regarded as a therapeutic agent. Recent evidence has shown that hydrogen is a potent antioxidative, antiapoptotic and anti-inflammatory agent and so may have potential medical applications in cells, tissues and organs…

Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect

The purpose of the current study was to evaluate hydrogen-saturated saline protecting intensive narrow band noise-induced hearing loss. Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily…

Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats

Background: Although the benefits of ex vivo lung perfusion (EVLP) have been globally advocated, the potentially deleterious effects of applying EVLP, in particular activation of proinflammatory cascades and alteration of metabolic profiles, are rarely discussed. This study examined proinflammatory…

Application of Hydrogen Producing Microorganisms in Radiotherapy: An Idea

Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated encephalopathy

To evaluate protective effects of inhaled hydrogen gas (H2) on cognitive function in a murine model of sepsis-associated encephalopathy (SAE). A total of 84 male ICR mice, weighing 20-25 g, aged 6-8 weeks, were randomly divided into 4 groups of sham, sham+H2, sepsis and sepsis+H2. Sepsis was…

Neuroprotective effects of saturated hydrogen water on retinal ganglion cells in rat optic nerve crush model

Objective: To investigate the protective effect of saturated hydrogen water on the retinal ganglion cells (RGC) of the rat optic nerve crush model. Design: Experimental study. Participants: Eighteen healthy adult male SD rats. Methods: Eighteen SD rats were randomly divided into the A, B and C…

The preliminary study on the inhibiting effect of saturated hydrogen water on suture induced corneal neovascularization in rats

Objective To investigate the inhibiting effect of saturated hydrogen water on suture induced corneal neovascularization in rats. Design Experimental study. Participants Healthy adult male SD rats. Methods The left eyes of SD male rats were selected as the experimental eyes. The suture induced…

Regulative effect of hydrogen on oxidative stress level of placental ischemia-reperfusion cell model of preeclampsia

Objective To investigate the effects of hydrogen on cell protection of placental ischemia-reperfusion cell model of preeclampsia and its possible mechanism. Methods JAR cells cultured in vitro were divided into five groups, i.e. the blank control group, saturated hydrogen group under normal oxygen…

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress…

Attenuation of diffuse axonal injury by intraperitoneal injection of hydrogen via reducing oxidative stress in rats

To investigate the role of oxidative stress in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI models. Methods Totally 118 adult male SD rats were divided into 3 groups with 39 in each: sham, DAI, and DAI + hydrogen treatment. Rat diffuse axonal injury was induced…

A novel fluid resuscitation protocol: Provide more protection on acute kidney injury during septic shock in rats

Objective: To investigate the therapeutic effects of a novel fluid resuscitation protocol (early fluid resuscitation plus 2% hydrogen inhalation) on acute kidney injury during septic shock induced by lipopolysaccharide in rats. Methods: Sixty male Wistar rats were randomly divided into four groups…

Protective effects of hydrogen-rich saline against γ-ray irradiation-induced injury in kidney epithelial HK-2 cells

Objective To investigate the protective effects and mechanism of Hydrogen-rich saline against γ irradiation-induced injury in HK-2 cells. Methods HK-2 cells were separated into 4 groups: the contral group, the Hydrogen-treated group, the irradiated group, the irradiated Hydrogen-treated group…

Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species

Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. We…

Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement

Traumatic brain injury (TBI) is the most important cause of disability in individuals under the age of 45 years and thus represents a significant social and economic burden. Evidence strongly suggests that oxidative stress is a cornerstone event leading to and propagating secondary injury…

Protective effect of hydrogen on colon injuries

Hydrogen is a therapeutic medical gas. Studies have shown that hydrogen has antioxidant, anti-inflammatory and anti-apoptotic effects, selectively inhibiting cytotoxic oxygen free radicals, and playing a protective role in ischemia-reperfusion injury, inflammatory diseases, metabolic syndrome…

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

The present study was designed to test the hypothesis that long-term treatment with hydrogen-rich saline abated testicular oxidative stress induced by nicotine in mice. The effects of hydrogen-rich saline (6 ml/kg, i.p.), vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) on reproductive…

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

During the development of sepsis, the complication in central nervous system (CNS), appearing early and frequently relative to other systems, can obviously increase the mortality of sepsis. Moreover, sepsis survivors also accompany long-term cognitive dysfunction, while the ultimate causes…

Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene…