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Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats
Background: The present study aimed at investigating the effect of a novel antioxidant, hydrogen (H2) gas, on the severity of contrast-induced acute kidney injury (CIAKI) in a rat model. Methods: CIAKI was induced in rats by intravenous injection of a contrast medium, Ioversol, in addition…
Consumption of hydrogen water prevents the occurrence of neuropathic pain in mice
Beneficial Effects of Hydrogen Gas on Porcine Liver Reperfusion Injury With Use of Total Vascular Exclusion and Active Venous Bypass
Background Liver ischemia/reperfusion (I/R) injury is a high risk factor in liver transplantation and it influences graft survival. One of the major events during I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to have antioxidant properties…
Effect of hydrogen-rich water on acute peritonitis of rat models
Objective: To study the effect of hydrogen-rich water (HRW) on acute peritonitis with three different rat models. Methods: Acute peritonitis was induced by three methods including intraperitoneal injection of lipopolysaccharide (LPS), rats' feces or cecal ligation and puncture (CLP) operation…
Effects of hydrogen-rich water on aging periodontal tissues in rats
Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues…
Hydrogen-rich water affected blood alkalinity in physically active men
Possible appliance of effective and safe alkalizing agent in the treatment of metabolic acidosis could be of particular interest to humans experiencing an increase in plasma acidity, such as exercise-induced acidosis. In the present study we tested the hypothesis that the daily oral intake of 2L…
Molecular hydrogen attenuates neuropathic pain in mice
Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections…
Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats
Background: Rhabdomyolysis is a leading cause of acute kidney injury. The pathophysiological process involves oxidative stress and inflammation. Hydrogen-rich saline (HRS) is an antioxidant and anti-inflammatory. This study explored the protective effect of pretreatment with HRS on the development…
Review and prospect of the biomedical effects of hydrogen
Hydrogen, the simplest gas in nature, was recently reported as a therapeutic antioxidant through selectively reducing cytotoxic oxygen radicals. Though hundreds of studies on curative effects of hydrogen were published and justified, the mechanism remains unclear. We proposed several promising…
Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: Study protocol for a randomized controlled trial
Background The failures of recent studies intended to prevent cerebral vasospasm have moved the focus of research into delayed cerebral ischemia away from cerebral artery constriction towards other mechanisms. Recent accumulating evidence has suggested that early brain injury is also involved…
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water
Abstract Background Hydrogen has been reported to relieve damage in many disease models, and is a potential additive in drinking water to provide protective effects for patients as several clinical studies revealed. However, the absence of a dose–response relationship in the application of hydrogen…
Protective effects of hydrogen on renal ischemia/reperfusion injury in rats
To investigate the protective effects of hydrogen on renal ischemic/reperfusion injury and its mechanism in rats. Eighteen adult male Sprague-Dawley rats were used and allocated into sham-operated group (Sham group), ischemic reperfusion group (I/R group) and hydrogen treated group (H2 group)…
Neuroprotective effects of saturated hydrogen water on retinal ganglion cells in rat optic nerve crush model
Objective: To investigate the protective effect of saturated hydrogen water on the retinal ganglion cells (RGC) of the rat optic nerve crush model. Design: Experimental study. Participants: Eighteen healthy adult male SD rats. Methods: Eighteen SD rats were randomly divided into the A, B and C…
Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats
Background: Although the benefits of ex vivo lung perfusion (EVLP) have been globally advocated, the potentially deleterious effects of applying EVLP, in particular activation of proinflammatory cascades and alteration of metabolic profiles, are rarely discussed. This study examined proinflammatory…
Relationship between exhaled hydrogen and human neutrophil function in the Japanese general population
We examined the relationship between the amount of exhaled hydrogen and neutrophil ROS production to investigate the effect of hydrogen on oxidative stress at normal state among the general population comprising subjects who had participated in 'The Iwaki Health Promotion Project in 2007', which…
Effects of hydrogen-rich saline on liver of severely scalded rats with delayed resuscitation
To explore the effects of hydrogen-rich saline (HS) on liver of severely scalded rats with delayed resuscitation. Twenty-four SD rats were inflicted with 40% TBSA full-thickness scald using a temperature-controlled scalding apparatus. The injured rats were divided into lactated Ringer's solution…
Application of Hydrogen Producing Microorganisms in Radiotherapy: An Idea
Hydrogen supplementation of preservation solution improves viability of osteochondral grafts
Allogenic osteochondral tissue (OCT) is used for the treatment of large cartilage defects. Typically, OCTs collected during the disease-screening period are preserved at 4°C; however, the gradual reduction in cell viability during cold preservation adversely affects transplantation outcomes…
Hydrogen-rich saline attenuates ischemia–reperfusion injury in skeletal muscle
Background: To investigate the potential beneficial effect of hydrogen-rich saline (HRS) in ischemia-reperfusion (IR) injury of skeletal muscle. Methods: Three experimental groups were established in male Sprague-Dawley rats: (1) sham group, (2) IR with normal saline group, (3) and IR with HRS…