All Studies
2,276 studies foundSort & Filter
Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells <i>in vitro</i>
In the last decade, many studies have shown that hydrogen gas or hydrogen water can reduce the levels of reactive oxygen species in the living body. Molecular hydrogen has antioxidant and antiapoptotic effects and a preventive effect on oxidative stress-induced cell death. In the present study, we…
Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels
Objectives: The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen…
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans
Background: Hydrogen gas inhalation (HI) reduced infarct size and mitigated adverse left ventricular (LV) remodeling in a rat model of acute myocardial infarction (AMI). We designed a prospective, open-label, rater-blinded clinical pilot study in patients experiencing ST-elevated MI (STEMI).Methods…
Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats
The aim of the current study was to identify the protective effect of hydrogen gas against liver injury during CO2 pneumoperitoneum. Rats were randomly divided into three groups: control group (C group), pneumoperitoneum group (P15 group) and hydrogen group (H2 group). Rats in the C group were…
Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats
To study how hydrogen-rich saline (HS) promotes the recovery of testicular biological function in a hemi-sectioned spinal cord injury (hSCI) rat model, a right hemisection was performed at the T11-T12 of the spinal cord in Wistar rats. Animals were divided into four groups: normal group; vehicle…
Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model
The aim of the present study was to investigate the effects of intraportal administration of hypothermic hydrogen-rich saline solution (HRSS) on hepatic ischemia/reperfusion (I/R) injury. Thirty rats were divided equally into six groups; 1) sham, no I/R or transfusion, 2) I/R injury (60 minutes…
Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats
Background: In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical…
Sufficient intake of high amylose cornstarch maintains high colonic hydrogen production for 24 h in rats
AbstractColonic hydrogen (H2) can suppress oxidative stress and damage in the body. We examined the minimum requirement of high amylose cornstarch (HAS) to maintain high colonic H2 production for 24 h. Ileorectostomized and sham-operated rats were fed a control diet supplemented with or without 20%…
Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis
Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson's disease in animal and clinical studies. However, the molecular mechanisms…
Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice
Objectives: To examine the effect of hydrogen water (HW) on the severity of atopic dermatitis (AD) and elucidate the underlying pathophysiological mechanisms. Methods: For this experimental study between March 2015 and December 2015, NC/Nga mice characterized by mild AD severity were given either…
Fundamental Insight into the Methodology of Hydrogen Water in Biological Studies
In this short review, we have summarized our recent findings about hydrogen water, focusing on the methods for generating hydrogen water, in vivo and in vitro safety tests, and the antioxidant effect and anticancer effect of hydrogen water. Our findings indicate that a portable, inexpensive…
Effects of Hydrogen-Rich Saline on Hepatectomy-Induced Postoperative Cognitive Dysfunction in Old Mice
This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). Ninety-six old male Kunming mice were randomly divided into 4 groups (n = 24…
Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress
Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine…
Discussion: Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model
Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress
Background: It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has…
Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: a pilot study
Molecular hydrogen is an experimental therapeutic agent in biomedicine, however its effects on serum antioxidant markers are poorly described so far. Sixteen healthy men (age 24.6 ± 3.6 years, height 183.3 ± 4.4 cm; weight 83.5 ± 12. 5 kg) participated in this randomized, double blind…
Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy
Objective: To investigate the role of autophagy in hydrogen-rich saline attenuating post-herpetic neuralgia( PHN) in rats. Methods: A total of 100 male SD rats were randomly divided into the five groups( n = 20) : control group,PHN group,PHN group treated with hydrogen-rich saline( PHN-H2group),PHN…
Functional water ‒ in promotion of health beneficial effects and prevention of disease
Functional water science has gained attention recently in response to its physiological functions, health-promoting effects and disease prevention, especially on oxidative-stressrelated diseases such as diabetes, cancer, arteriosclerosis, neurodegenerative diseases and side effects of hemodialysis…
Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil
Objective: Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. Methods: The animals were subjected to transient cochlear ischemia by occluding the bilateral vertebral arteries for l5min. Five…