All Studies
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Efficacy of silicon-based agent against aging-related frailty
Increasing aging populations globally have made maintaining a healthy life expectancy for older adults a critical issue. Older adults are particularly susceptible to frailty, physical and mental vulnerability caused by age-related decline in physiological and psychological resilience. Preventing…
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy
ABSTRACT Objective Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study developed a hydrogen‐enriched hyaluronic acid (HA) dressing and aimed to explore its therapeutic effects and mechanisms in DFU treatment. Methods A combination of vacuum‐assisted…
Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report
Background/aim: The management of Stage II empyema complicated by chronic inflammatory demyelinating polyneuropathy (CIDP) presents a formidable clinical challenge due to the precarious balance required between aggressive infection control and the modulation of immune-mediated neurological frailty…
Hydrogen-Rich Saline Accelerates Diabetic Wound Healing in Vivo and Its Interaction with the Renin-Angiotensin System Pathway
Aim: Oxidative stress and chronic inflammation represent two major contributors to slowing the process of diabetic wound healing. So far, there is a lack of characterization of the mechanistic role of hydrogen-rich saline (HRS), despite its antioxidant potential, in diabetic wound repair. This…
Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy
Glaucoma-induced optic nerve damage is known to be a leading cause of blindness worldwide, yet current therapies mainly focus on reducing intraocular pressure without paying significant attention to the oxidative stress and inflammation in ocular tissues. Here, we address this issue by developing…
Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report
Background/aim Behçet's Disease is a systemic vasculitis affecting both venous and arterial vessels, characterized by painful oral and genital ulcers. Primary Sjögren's Syndrome is an autoimmune disorder mainly targeting exocrine glands, especially the salivary and lacrimal glands, with possible…
Individual variability in hydrogen-producing microbes influences the response to hydrogen supplementation on sleep quality: a randomized, double-blind, placebo-controlled, parallel study
Hydrogen has been reported to exert antioxidant and anti-inflammatory effects, and its potential health benefits have been investigated. However, to our knowledge, evidence regarding its impact on sleep quality in healthy individuals remains extremely limited. In addition, the influence…
The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials
Objective: Obesity-related dyslipidemia remains a significant health challenge, contributing to increased cardiovascular risk. Hydrogen-rich water (HRW) has been proposed as a potential adjunctive intervention due to its antioxidant and anti-inflammatory properties. This systematic review…
Association of Self-Selected Hydrogen-Rich Water Consumption with 6-Month Changes in Chair-Stand Performance and Gait Speed among Community-Dwelling Older Adults Attending Community Salons
To examine whether self-selected hydrogen-rich water consumption was associated with 6-month changes in physical function among community-dwelling older adults attending community salons. This prospective observational study included 128 older adults in Hiroshima, Japan. Participants were…
Metabolomic Alterations Associated with Adjunctive Hydrogen Gas Inhalation During Concurrent Chemoradiotherapy in Locally Advanced Head and Neck Cancer: A Pilot Study
Background: H2 gas inhalation has been proposed as a selective modulator of reactive oxygen species (ROS), potentially mitigating treatment-related oxidative damage. This study investigated the effects of adjunctive H2 gas inhalation on serum metabolomic profiles and clinical toxicities in patients…
Molecular Hydrogen Reverses Sepsis-induced Immunoparalysis: Insights from Longitudinal Deep Immunophenotyping
Background/aim: Refractory septic shock and post-cardiac arrest syndrome (PCAS) can induce lethal immunoparalysis. However, longitudinal evidence on the effects of molecular hydrogen on deep human immunophenotyping remains scarce. Case report: We report the case of a 49-year-old man with severe…
Clinical Trial: Randomised Placebo-Controlled Trial of Methylcellulose and Psyllium Gels on Inulin-Induced Colonic Gas
Background: People with irritable bowel syndrome (IBS) often restrict their intake of FODMAPs because of associated gas and abdominal discomfort. Psyllium, a gel-forming fibre, reduces colonic gas after inulin ingestion. Objective: We aimed to determine whether methylcellulose, a low-cost…
Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice
Aims: Acute aortic dissection (AAD) is a life-threatening condition in which vascular inflammation contributes to disease progression and complications such as aortic rupture. Current treatment is centered on hemodynamic control, and anti-inflammatory options remain limited. We investigated whether…
Hydrogen gas (H2) pretreatment improves lipopolysaccharide-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation and pyroptosis signaling
Background The liver is extremely vulnerable to endotoxin-induced damage during sepsis. Hydrogen gas (H 2 ) is a colorless and odorless gas molecule with anti-oxidative and anti-inflammatory actions. However, the effects of H 2 intraperitoneal injection on sepsis-induced acute liver injury…
Hydrogen reshapes the senescent microenvironment of callus to enhance the healing of anti-osteoporotic-drug-induced atypical femoral fracture
Long-term bisphosphonates (BPs) are widely used to treat osteoporosis, however, they are paradoxically associated with the development of atypical femoral fractures (AFFs), which often characterized by impaired healing. In this study, we induced an AFF model using zoledronate (ZOL) administration…
Hydrogen Nanobubbles Inhibit Oxidative Stress and Myocardial Fibrosis to Reverse Chemotherapy-Induced Myocardial Injury
The most severe side effect of chemotherapy is cardiotoxicity, frequently causing myocardial injury characterized by excessive oxidative stress and fibrosis for which effective treatments are lacking. To address this, a hydrogen delivery system, hydrogen nanobubbles (HNBs), was constructed…
Selective Antimicrobial Activity of Slightly Acidic Electrolyzed Water: Differential Effects on Harmful and Beneficial Bacteria in Microbial Fermentation Systems
Microbial contamination in fermentation systems poses significant risks to safety and efficiency, as harmful microbes can proliferate while conventional disinfectants often indiscriminately harm beneficial lactic acid bacteria (LAB). This study investigated the selective antimicrobial activity…
Inflamed vessel–anchored release of H <sub>2</sub> across the blood-brain barrier for ischemic stroke neuroprotection
Ischemic stroke followed by reperfusion urgently requires safe and efficient cytoprotective strategies, a need still unmet by current pharmacotherapies. Nanotechnology holds promise for improved drug delivery to the brain, yet the efficacy of nanomaterials crossing the blood-brain barrier (BBB)…
Adjuvant Molecular Hydrogen Facilitates Immunosuppressant Tapering and Sustained Remission in Systemic Lupus Erythematosus: A Case Report
Background/aim: Management of systemic lupus erythematosus (SLE) remains challenging: intensive immunosuppression increases infection risk, whereas dose reduction may trigger disease flares. Molecular hydrogen (H2), a selective antioxidant with anti-inflammatory properties, may serve as an adjunct…
Research progress on the preventive and therapeutic effects of hydrogen in oxidative stress-induced pulmonary diseases
Oxidative stress, inflammatory response, and cell apoptosis play important roles in the occurrence, development, and outcome of many diseases, including some lung diseases. During ischemia, hypoxia, or inflammation, the body produces excessive reactive oxygen species (ROS), which non-selectively…