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Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials
Background: Mounting evidence indicates that hydrogen gas (H2) is a versatile therapeutic agent, even at very low, non-combustible concentrations. The Chinese National Health and Medical Commission recently recommended the use of inhaled H2 in addition to O2 therapy in the treatment…
Molecular hydrogen: A potential radioprotective agent
In recent years, many studies have shown that hydrogen has therapeutic and preventive effects on various diseases. Its selective antioxidant properties were well noticed. Most of the ionizing radiation-induced damage is caused by hydroxyl radicals (OH) from radiolysis of H2O. Since hydrogen can…
Perspective of molecular hydrogen in the treatment of sepsis
Sepsis is the main cause of death in critically ill patients with no effective treatment. Sepsis is lifethreatening organ dysfunction due to a dysregulated host response to infection. As a novel medical gas, molecular hydrogen (H2) has a therapeutic effect on many diseases, such as sepsis. H2…
Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty
In today's society, healthy skin and a beautiful appearance are considered the foundation of general well-being. The skin is the largest organ of the body and plays an important role in protecting it against various factors such as environmental, physical, chemical, and biological hazards. These…
Molecular hydrogen application in stroke: bench to bedside
Stroke is a major cause of mortality and morbidity worldwide. Effective treatments are limited. Molecular hydrogen is emerging as a novel medical gas with therapeutic potential for various neurological diseases, including stroke. We reviewed the experimental and clinical findings of the effects…
Development of Molecular Hydrogen Medicine
As research activities progressed, effects of molecular hydrogen (MH) proved to be more extended than previously expected. In parallel with exploratory experiments with animals, human clinical trials have also been performed and yielded positive results in most cases. Here I begin with animal…
From the Front-Line of Research: Interviews
From what has been described thus far, the readers have probably learned how Molecular Hydrogen Medicine emerged and developed as a new field of medicine, and what its current situation is. Since many medical effects of molecular H2 were far beyond expectations, the reports were often viewed…
Molecular Hydrogen for Medicine
This book provides a comprehensive account of the current status of molecular hydrogen medicine, a young field that emerged with the discovery that inhalation of hydrogen gas leads to the elimination of harmful reactive oxygen species in rats. Various physiologic effects have since been…
Preparation, Handling, and Usage of Hydrogen
Description is given of some examples of instrumentations developed for medical applications, and some basic properties of hydrogen water as supplement for the interest of general readers.
The Future of Molecular Hydrogen Medicine
The application of MHM has so far been largely limited to patients under grave condition or suffering from chronic diseases, but in the near future, it will be extended to many ‘ordinary’ diseases. Then, while the low cost of MHM is a godsend for patients, it will pose serious problems…
Mechanisms Underlying the Biological Effects of Molecular Hydrogen
Aberrant redox-sensitive reactions and accumulation of oxidative damage can impair body functions and contribute to the development of various pathologies and aging. Although antioxidant substances have long been recognized as a measure of alleviating oxidative stress and restoring redox balance…
EVOLUTION, ADAPTIVE STRESSORS AND MOLECULAR HYDROGEN
Molecular hydrogen (H2) has demonstrated therapeutic properties across numerous models. To date, the mechanism underlying the beneficial responses toH2 exposure remains elusive. The initial hypothesis that molecular hydrogen acts as a direct, selective antioxidant in vivodoes not reconcile models…
RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways
Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in DMEM medium with or without hydrogen. RNA sequencing was used to explore the association of hydrogen treatment…
Hydrogen: An Endogenous Regulator of Liver Homeostasis
Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2…
Strategies for engineering advanced nanomedicines for gas therapy of cancer
As an emerging and promising treatment method, gas therapy has attracted more and more attention for treatment of inflammation-related diseases, especially cancer. However, therapeutic/therapy-assisted gases (NO, CO, H2S, H2, O2, SO2 and CO2) and most of their prodrugs lack the abilities of active…
Advances in the Protective Mechanism of NO, H2S, and H2 in Myocardial Ischemic Injury
Myocardial ischemic injury is among the top 10 leading causes of death from cardiovascular diseases worldwide. Myocardial ischemia is caused mainly by coronary artery occlusion or obstruction. It usually occurs when the heart is insufficiently perfused, oxygen supply to the myocardium is reduced…
Functions of Heavy Water in Living Organisms
After a brief survey of physiological actions of heavy water, recent medical applications for organ transplant are explained in some detail. Organ preservation utilizing heavy water solutions was found to be far more effective than existing preservation solutions. This advancement…
Hydrogen Studies at ClinicalTrials.gov: The Dawn of a New Era?
Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury in rat models
Background: Hydrogen gas exists in the atmosphere and was previously considered an inert gas. It has been reported to have protective effects on tissue ischemia-reperfusion (IR) injuries in animal models. The protective mechanism of hydrogen molecules is based on selectively reducing highly strong…
Gas-Mediated Cancer Bioimaging and Therapy
Gas-involving cancer theranostics have attracted considerable attention in recent years due to their high therapeutic efficacy and biosafety. We have reviewed the recent significant advances in the development of stimuli-responsive gas releasing molecules (GRMs) and gas nanogenerators for cancer…