All Studies

Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and inflammatory response

The small intestine is known to be particularly sensitive to radiation, and the major limiting factor of radiotherapy is the gastrointestinal syndrome that subsequently develops after its administration. The detrimental effects of radiation are mostly mediated via the overproduction of reactive…

Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet

Studies have shown that metabolic diseases, such as obesity, are significantly associated with intestinal flora imbalance. The amplification of opportunistic pathogens induced by the glyoxylic acid cycle contributes to intestinal flora imbalance. Promising, though, is that saturated hydrogen can…

Hydrogen water alleviates obliterative airway disease in mice

Objective: Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative…

Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial

We analysed the effects of an experimental novel protocol of intensive hydrotherapy with hydrogen-rich water (HRW) on injury recovery in athletic men who suffered an acute ankle sprain (AAS) and compared it with a RICE protocol (rest, ice, compression, elevation). Professional athletes (age 23.7…

Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats

Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements in hydrogen (H2) gas offer a promising therapeutic approach for ischemia reperfusion injury; however, the impact of this approach for HIE remains a subject…

Effect of hydrogen inhalation on IL-40 and SIgA in a Rat Model of Pulmonary Mucosal Immunity

Background Recently, some researchers have reported that PIgR expression is down-regulated in Chronic Obstructive Pulmonary Disease (COPD) and SIgA deficiency correlates with severity of airflow obstruction. What’ s more, some studies have demonstrated that 2 percent of hydrogen or hydrogen water…

The Power of Hydrogen Molecules Uncovered

After some sporadic reports, a seminal paper of Ohsawa et al. (Nat. Med. 13:688–694, 2007) was published that clearly demonstrated physiological and therapeutic effects of molecular hydrogen (MH), and opened a new area of medicine to be called Molecular Hydrogen Medicine (MHM).

Physiological Effects of the Hydrogen Molecules

Following the introduction to the medical effects of H2 molecules, this section summarizes some basic physiological effects of molecular H2 and its mechanism of action on diseases. It should be noted that the molecular hydrogen discussed here is a completely different entity from ions. Positive…

Polymers producing hydrogen

Some Fundamental Properties of Hydrogen and Water

Some physical and chemical properties of hydrogen and water, underlying their characteristic physiological properties are described. Selected topics include hydrogen bonding in water, tunneling mechanism in atomic/molecular migration, and Grotthuss mechanism of hydrogen migration in water.

New approaches for hydrogen therapy of various diseases

Hydrogen therapy has recently received increasing attention as an emerging and promising therapeutic technology due to its selective antioxidant property and cell energy regulatory capability in vivo. To solve the low solubility issue of hydrogen, a variety of nanomaterials and devices for hydrogen…

The Potential of Hydrogen for Improving Mental Disorders

In 2007, Ohsawa and colleagues reported that molecular hydrogen (H2) gas significantly reduced the infarct volume size in a rat model of cerebral infarction, which was, at least, partially due to scavenging hydroxyl radicals. Since then, multiple studies have shown that H2 has not only…

A narrative review of hydrogen-oxygen mixture for medical purpose and the inhaler thereof

Recent development regarding mixture of H2 (concentration of ~66%) with O2 (concentration of ~34%) for medical purpose, such as treatment of coronavirus disease-19 (COVID-19) patients, is introduced. Furthermore, the design principles of a hydrogen inhaler which generates mixture of hydrogen (~66%)…

Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

There are many situations of excessive production of reactive oxygen species (ROS) such as radiation, ischemia/reperfusion (I/R), and inflammation. ROS contribute to and arises from numerous cellular pathologies, diseases, and aging. ROS can cause direct deleterious effects by damaging proteins…

Proposal of next-generation medical care “Mega-hydrogen Therapy”

Hydrogen: A Novel Option in Human Disease Treatment

H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs…

Hydrogen Is Promising for Medical Applications

Hydrogen (H2) is promising as an energy source for the next generation. Medical applications using H2 gas can be also considered as a clean and economical technology. Since the H2 gas based on electrolysis of water production has potential to expand the medical applications, the technology has been…

A 'philosophical molecule,' hydrogen may overcome senescence and intractable diseases

It has been revealed that the cause of senescence and diseases is associated with the reactive oxygen species 'hydroxyl radicals' (·OH). Senescence and diseases may be overcome as long as we can scavenge •OH mostly produced in mitochondria. It is one and only one 'molecular hydrogen' (H2) that can…

Biological Responses to Hydrogen Molecule and its Preventive Effects on Inflammatory Diseases

Because multicellular organisms do not have hydrogenase, H2 has been considered to be biologically inactive in these species, and enterobacteria to be largely responsible for the oxidation of H2 taken into the body. However, we showed previously that inhalation of H2 markedly suppresses brain…

Direct targets and subsequent pathways for molecular hydrogen to exert multiple functions: Focusing on interventions in radical reactions

Molecular hydrogen (H2) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 has multiple functions in addition to antioxidant…