All Studies

Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression

Objective: To investigate the effects of hydrogen water on proliferation, differentiation, collagen secretion and Nrf2 expression in paraquat-induced human lung fibroblasts. Methods: In vitro cultured human lung fibroblasts (HFL1) exposed to 600 μmol/L paraquat (PQ) for 24 h were treated…

Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

Hydrogen gas can mitigate oxidative stress in many diseases that is regarded to be safe and free of side effect. Inspired by a metalloenzyme in a variety of microorganisms, here we propose a photo-activated H2 nanogenerator that comprises a fluorinated chitosan (FCS), a chemotherapeutic drug…

Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study

Aerobic exercise is widely accepted as a beneficial option for reducing fat in humans. Recently, it has been suggested that molecular hydrogen (H2) augments mitochondrial oxidative phosphorylation. Therefore, the hypothesis that inhaling H2 could facilitate lipid metabolism during aerobic exercise…

1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats

Purpose Hydrogen gas (H2) inhalation improved the survival rate of hemorrhagic shock. However, its mechanisms are unknown. We hypothesized that H2 protected the endothelial glycocalyx during hemorrhagic shock and prolonged survival time. Methods 83 Sprague–Dawley rats were anesthetized…

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

Background: Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might initiate…

Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway

Sepsis-associated encephalopathy (SAE) is a cognitive impairment caused by sepsis and is related to increased morbidity and mortality. Damage to the blood-brain barrier (BBB) has been proved to be one of the important causes of SAE. Molecular hydrogen (H2) is a promising method for the treatment…

Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace-Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial

Oxidative stress has been associated with many diseases as well as aging. Electrolyzed-reduced water (ERW) has been suggested to reduce oxidative stress and improve antioxidant potential. This study investigated the effects of drinking ERW on biomarkers of oxidative stress and health-related…

Hydrogen rich water ameliorate Trimethyltin induced spatial learning and memory impairment by regulation of Siah-1

Abstract Background: As an important member of organic tin compounds, Trimethyltin (TMT) exists widely in industrial and agricultural productions. TMT can induce significant neurodegeneration in the limbic system, particular in hippocampus. However, the molecular mechanisms in TMT-induced learning…

Hydrogen vs. Caffeine for Improved Alertness in Sleep-Deprived Humans

Molecular hydrogen (H2) has been suggested as an agent capable of exerting neuromodulating effects; yet, its potential to affect brain circuits linked to alertness remains poorly examined. In this randomized controlled cross-over pilot trial, we compared acute effects of single-dose hydrogen-rich…

Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer

Chemotherapy, targeted therapy, and immunotherapy are used against advanced non-small cell lung cancer. A clinically efficacious method for relieving the adverse events associated of such therapies is lacking. Fifty-eight adult patients were enrolled in our trial to relieve pulmonary symptoms…

Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure <i>in vitro</i> and <i>in vivo</i>

Radionuclide tritium is widely used in the nuclear energy production industry and creates a threat to human health through radiation exposure. Herein, the radioactive elimination and radioprotective effect of hydrogen-rich water (HRW), a potential antioxidant with various medical applications…

Exercise-Driven Increase in Gut Microbial Hydrogen Production as a Possible Factor of Metabolic Health

Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress

Molecular hydrogen is thought to have an inhibitory effect on oxidative stress, thereby attenuating the onset and progression of various diseases including cardiovascular disease; however, few reports have assessed the preventive effect of constitutive inhalation of hydrogen gas on of vascular…

Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study

The various beneficial effects of the intake of molecular hydrogen (H2) have been demonstrated in the field of sports science. Although supplementation of H2 has been reported to increase mitochondrial metabolism in animal studies, the effects of the administration of H2 on aerobic capacity during…

Protective effects of hydrogen on oxidative stress and liver function during CO2 pneumoperitoneum in dogs

The purpose of this study was to investigate the protective effects of hydrogen reducing ischemia-reperfusion injury during CO2 pneumoperitoneum on oxidative stress and liver function. Eighteen healthy Beagle dogs were divided into three groups. Dogs in the control group were subjected only…

Letter: balancing gut hydrogen as a proxy for bacteriotherapy benefits in irritable bowel syndrome

LINKED CONTENTThis article is linked to Ianiro et al paper. To view this article, visit https://doi.org/10.1111/apt.14201.

Does drinking water rich in hydrogen gas revive brain hypometabolism in neurodegeneration by SCFAs upregulation?

Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions. Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia…

Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model

Aim: To investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn. Methods: In each rat, one cornea was subjected to alkali exposure. Physiological saline (saline group) or H2-dissolved saline (H2 group) was instilled…

NIR-Driven Water Splitting H₂ Production Nanoplatform for H₂-Mediated Cascade-Amplifying Synergetic Cancer Therapy

As a newly emerging treatment strategy for many diseases, hydrogen therapy has attracted a lot of attention because of its excellent biosafety. However, high diffusivity and low solubility make it difficult to accumulate in the local lesions. Herein, we develop H2 self-generation nano-platform…