All Studies

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines

Hydrogen gas (H(2)) as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable for clinical application. The present study was designed to investigate whether HS can offer…

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously reported marked effects of ad libitum administration of hydrogen water on prevention of a rat…

Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism

Application of an Electrolyzed Strongly Acidic Aqueous Solution Before Wound Closure in Colorectal Surgery

Electrolyzed strongly acidic aqueous solution which is produced by electrolysis of a sodium chloride solution has been used in Japan for the irrigation of wounds or body cavities even in the absence of particular evidence. The purpose of this study is to investigate the efficacy or harmful effects…

Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model

Hydrogen has been reported to selectively quench detrimental reactive oxygen species, particularly hydroxyl radical, and to prevent myocardial or hepatic ischemia/reperfusion injury in multiple models. The aim of this study is to investigate whether hydrogen protects against severe burn-induced…

Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats

Recently it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals (·OH) and peroxynitrite anion (ONOO-) in vitro and exert therapeutic antioxidant activity in many diseases. This study was designed to investigate the effect of hydrogen-rich saline…

Hydrogen Inhalation is Neuroprotective and Improves Functional Outcomes in Mice After Intracerebral Hemorrhage

Oxidative stress contributes significantly to the development of secondary brain injury after intracerebral hemorrhage (ICH). It has been previously demonstrated that hydrogen gas can decrease oxidative stress by scavenging reactive oxygen species. We hypothesized that hydrogen therapy will reduce…

Saturated hydrogen saline protects against noise–induced hearing loss

Objective: To study effects of saturated hydrogen saline in preventing noise–induced hearing loss. Methods: Fifteen guinea pigs were randomly divided into 3 groups (5 each), group one was for control, group two was treated with normal saline and group three was treated with saturated hydrogen…

Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated…

Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis

Inhalation of hydrogen gas has been proven to be an effective treatment for ischemia-reper-fusion injury by selectively reducing hydroxyl and peroxynitrite radicals. There has been con-siderable evidence of hydrogen's protective effect against diseases related to oxidative injury, such…

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates…

Hydrogen and Medical Application

A number of basic and clinical researches have revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs, with properties to mitigate various disease status. Recently, hydrogen gas has been…

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice

Sleep apnea syndrome increases the risk of cardiovascular morbidity and mortality. We previously reported that intermittent hypoxia increases superoxide production in a manner dependent on nicotinamide adenine dinucleotide phosphate and accelerates adverse left ventricular (LV) remodeling. Recent…

Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus

Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these cells play a crucial role in cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels in insulin-producing cells…

Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in <i>db/db</i> Mice

Recent extensive studies have revealed that molecular hydrogen (H 2 ) has great potential for improving oxidative stress‐related diseases by inhaling H 2 gas, injecting saline with dissolved H 2 , or drinking water with dissolved H 2 (H 2 ‐water); however, little is known about the dynamic movement…

Saturated hydrogen saline protects rats from acutelung injury induced by paraquat

Background: Paraquat (PQ) intoxication causes lung oxidative stress damage. Saturated hydrogen saline, a newly explored antioxidant, has been documented to play a powerful antioxidant role in preventing oxidative stress damage. This study aimed to investigate the protective effects and the possible…

DRINKS WITH ALKALINE NEGATIVE OXIDATIVE REDUCTION POTENTIAL IMPROVE EXERCISE PERFORMANCE IN PHYSICALLY ACTIVE MEN AND WOMEN: DOUBLE-BLIND, RANDOMIZED,PLACEBO-CONTROLLED, CROSS-OVER TRIAL OF EFFICACY AND SAFETY

In the current study we tested the hypothesis that an acute (7 days) intake of an alkaline negative oxidative reduction potential formulation (NORP) drink would reduce the rate of blood lactate accumulation during and after exercise, increase time to exhaustion, increase serum buffering capacity…

Protective Effect of Hydrogen Gas Therapy After Germinal Matrix Hemorrhage in Neonatal Rats

Germinal matrix hemorrhage (GMH) is a neurological disease of very low birth weight premature infants leading to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Hydrogen (H2) is a potent antioxidant shown to selectively reverse cytotoxic oxygen-radical injury in the brain…

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.

Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice

Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mechanism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to determine the effect of ERW bathing on the UVB-induced skin injury in hairless…