All Studies
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Hydrogen May Inhibit Collagen-Induced Platelet Aggregation: An <i>ex vivo</i> and <i>in vivo</i> Study
Hydrogen selectively reduces hydroxyl radicals and peroxynitrite, and numerous experimental and clinical studies suggest that hydrogen can exert potent cellular protective effects against a wide variety of diseases. Furthermore, there is increasing evidence that antioxidants can modulate platelet…
Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning
This experiment was designed to determine whether hydrogen (H(2)) rich saline can ameliorate brain abnormalities in a rat model with acute carbon monoxide (CO) poisoning. Sprague-Dawley male rats were used for CO poisoning and H(2) rich saline treatment. Changes in neurons, microglias, and myelin…
Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig
Molecular hydrogen (H(2)) is an efficient antioxidant that can selectively reduce hydroxyl radicals and inhibit oxidative stress-induced injuries. We investigated the protective effects and mechanism of hydrogen-rich saline in a glutamate-induced retinal injury model. Retinal excitotoxicity was…
Protective Effects of Hydrogen Saline on Diabetic Retinopathy in a Streptozotocin-Induced Diabetic Rat Model
Abstract Purpose: Diabetic retinopathy is the leading cause of blindness in the working population of the developed countries and also a significant cause of blindness in the elderly. This study aimed at examining the protective effect of H 2 saline on diabetic retinopathy…
Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However…
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats
Hydrogen gas has been demonstrated to neutralize free radicals and reduce oxidative stress recently. Our objective was to determine the therapeutic effect of H2 inhalation and its antioxidative activity on early brain injury after subarachnoid hemorrhage. Controlled in vivo laboratory study. Animal…
Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs
To examine the efficiency of hydrogen-rich saline in the treatment of intensive noise-induced cochlear injury. Forty guinea pigs were assigned to one of four groups: HS+NOISE (i.p. injection hydrogen-rich saline), NS+NOISE (i.p. injection normal saline), NOISE ALONE (noise control), and NO…
Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters
Hydrogen (dihydrogen; H(2)) has an antiatherosclerotic effect in apolipoprotein (apo) E knockout mice. The goals of this study were to further characterize the effects of H(2) on the content, composition, and biological activities of plasma lipoproteins in golden hamsters. Plasma analysis…
Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits
Abstract Background Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema…
Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells
The influence of discharged hydrogen from Pd-Ni based hydrogen storage alloys (HSAs) on cultured cells has been investigated. The susceptibility of cells to discharged hydrogen varied with the kind of cells. No influence was seen in the normal cells, while an effect of killing cancer cells was…
Effects of ionized alkali water intake on oxidative stress and its related gene expression induced by acute and exhaustive exercise
The purpose of this study was to investigate the effects of ionized alkali water supplement on oxidative stress and proinflammatory cytokines in highly trained high school and college track athletes (n=18). In an single group and cross-over design, all subjects consumed tap water and ionized alkali…
Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture
Background: Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction. The present study was performed to investigate the effects of hydrogen-rich saline (HRS) on oxidative stress in the brain, cognitive dysfunction, and mortality in a rat model…
Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats
In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic…
Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis
Sepsis is the most common cause of death in intensive care units. Some studies have found that hyperoxia may be beneficial to sepsis. However, the clinical use of hyperoxia is hindered by concerns that it could exacerbate organ injury by increasing free radical formation. Recently, it has been…
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats
Aims: Arterialized vein grafts often fail due to intimal hyperplasia. Hydrogen potently protects organs and cells from many insults via its anti-inflammatory and antioxidant properties. We investigated the efficacy of oral administration of hydrogen-rich water (HW) for prevention of intimal…
Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema
AbstractBackgroundOxidative stress is thought to play an important role in the pathogenesis of inflammation. Recent studies have found that hydrogen gas has the effect of eliminating free radicals. Whether hydrogen saline (more convenient to be used than hydrogen gas) has the anti-inflammation…
Clinical effect and mechanism of alkaline reduced water
Recently, alkaline ionized water (AIW) generated by water electrolysis has received increasing attention because of its shown benefits in treatment and prevention of diseases. The Korean and the Japanese governments officially acknowledged the efficacy of AIW as a novel material for the improvement…
Advanced research on the health benefit of reduced water
In Japan, research on functional water, especially on reduced water, is developing at a rapid pace. Reduced water such as electrochemically reduced water and natural reduced water can scavenge reactive oxygen species in cultured cells. Reduced waters are expected to have preventive and positive…
A review of hydrogen as a new medical therapy
In the past few years many initial and subsequent clinical studies have demonstrated that hydrogen can act as an important physiological regulatory factor to cells and organs on the antioxidant, anti-inflammatory, anti-apoptotic and other protective effects. So far several delivery methods applied…
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress
Background: Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS. Our recent study shows that H(2) inhalation is beneficial to traumatic brain injury (TBI)…