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Studies Found: 590

NOSE - RHINITIS

Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via ...

Year Published: 2017

Background: It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. We herein ...
MOUTH - OBESITY

Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone ...

Year Published: 2017

Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. ...
LIVER - SLEEP APNEA

Improvement of hydrogen on liver oxidative stress injury in chronic intermittent hypoxia rats

Year Published: 2017

OBJECTIVE:To explore the effects of hydrogen on liver injury in chronic intermittent hypoxia rats and the related oxidative stress mechanism. METHODS:Twenty-four male adult SD rats were randomly divided into 3 groups(n=8):the normoxia group (Norm), the chronic intermittent hypoxia group (CIH), the chronic intermittent hypoxia and hydrogen group (H2 + CIH). Rats in Norm group were exposed in air, ...
MOUTH - GINGIVITIS

Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival ...

Year Published: 2017

The aim of the present study is to investigate protective effects of hydrogen-rich water (HW) against reactive oxygen species (ROS)-induced cellular harmful events and cell death in human gingival fibroblasts (HGF) and three-dimensional (3D-) gingival tissue equivalents. HW was prepared with a magnesium stick in 600-mL double distilled water (DDW) overnight. Dissolved hydrogen was about 1460 ± 50 ...
WHOLE BODY - AGING

Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative ...

Year Published: 2017

Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine sulfhydryl groups. Decreased Ca2+ signaling is observed in aged cells, probably secondary to the ...
WHOLE BODY - IMMUNE DYSFUNCTION

In Situ Nanoreactor for Photosynthesizing H 2 Gas To Mitigate Oxidative Stress in Tissue ...

Year Published: 2017

Hydrogen (H2) gas can reduce cytotoxic reactive oxygen spe-cies (ROS) that are produced in inflamed tissues. Inspired by natural photosynthesis, this work proposes a multicomponent nanoreactor (NR) that comprises chlorophyll a, L-ascorbic acid, and gold nanoparticles that are encapsulated in a liposomal (Lip) system that can produce H2 gas in situ upon photon absorption to mitigate inflammatory ...
BLOOD - SURGERY/TRANSPLANTATION

Antioxidants Attenuate Oxidative Stress-Induced Hidden Blood Loss in Rats

Year Published: 2017

Objective: Hidden blood loss (HBL), commonly seen after total knee or hip arthroplasty, causes postoperative anemia even after reinfusion or blood transfusion based on the visible blood loss volume. Recent studies demonstrated that oxidative stress might be involved in HBL. However, whether the antioxidants proanthocyanidin (PA) or hydrogen water (HW) can ameliorate HBL remains poorly understood. ...
BRAIN - ROS-SCAVENGING

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death ...

Year Published: 2017

Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson's disease in animal and clinical studies. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain unclear. Here, we investigated the ...
BRAIN - ANXIETY

Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats

Year Published: 2017

Background: In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis.Materials and methods: Natural reduced water and distilled water were administered to rats for 180 ...
BONE - OSTEONECROSIS

Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing ...

Year Published: 2017

Background: The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model. Methods: Sixty rabbits were randomly divided into two groups (model group and hydrogen group). Osteonecrosis was induced according to an established protocol of steroid-induced ON. Rabbits in the ...
WHOLE BODY - ROS-SCAVENGING

Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating ...

Year Published: 2017

Persistent oxidative stress is recognized as a major cause of many pathological conditions as well as ageing. However, most clinical trials of dietary antioxidants have failed to produce successful outcomes in treating oxidative stress-induced diseases. Molecular hydrogen (H2) has recently received considerable attention as a therapeutic agent owing to its novel antioxidant properties, a selective ...
BRAIN - NEUROPROTECTION

Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via ...

Year Published: 2017

Objectives: The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen species (ROS), mitochondrial dysfunction, and reduction in adenosine triphosphate (ATP) levels. This ...
EYE - CORNEAL INJURY

Retracted: Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative ...

Year Published: 2017

The aim of this study was to examine the effect of molecular hydrogen (H2) on the healing of alkali-injured cornea. The effects of the solution of H2 in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25 M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal ...
EYE - RADIOPROTECTION

Retracted: Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and ...

Year Published: 2017

The aim of this study is to examine whether molecular hydrogen (H2) is able to reduce oxidative stress after corneal damage induced by UVB irradiation. We previously found that UVB irradiation of the cornea caused the imbalance between the antioxidant and prooxidant enzymes in the corneal epithelium, followed by the imbalance between metalloproteinases and their physiological inhibitors ...
WHOLE BODY - FOOD POISONING

Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female ...

Year Published: 2018

The objective of the current experiment was to evaluate whether hydrogen-rich water (HRW) or lactulose (LAC) could protect against the adverse effects of Fusarium mycotoxins-contaminated diet on the growth performance and antioxidant status in weaning piglets. A total of 24 individually housed female piglets were randomly assigned to receive four treatments for 25 days (six pigs/treatment): ...
LUNG - ASTHMA

Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic ...

Year Published: 2018

Background Asthma is a worldwide common chronic airway disease that cannot be cured and results in the huge burden in public health. Oxidative stress was considered an important mechanism in the pathogenesis of asthma. Hydrogen gas been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases and the function of this nontoxic gas in asthma ...
SKIN - RADIOPROTECTION

Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells

Year Published: 2018

Chronic ultraviolet (UV) exposure-induced oxidative stress is associated with the pathogenesis of skin damage. However, the nuclear factor erythroid‑2‑related factor 2 (Nrf2) pathway is a critical factor in protecting cells against UVB‑induced injury through inhibiting oxidative stress. Furthermore, Nrf2 activation requires the involvement of the phosphoinositide-3 kinase (PI3K)/protein ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway

Year Published: 2018

Background: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly ...
BRAIN - NEUROPROTECTION

Hydrogenized Water Effects on Protection of Brain Cells from Oxidative Stress and Glutamate Toxicity

Year Published: 2018

Hydrogenized water is known to have protective effects on cells and tissues, mainly through its antioxidant activities. Here we examined the protective effects of a commercial source of hydrogenized water on cultured human brain cells. Hydrogenized water was able to protect brain cells from oxidative stress and glutamate toxicity. At H 2 concentrations above 0.01 mM the glutathione levels ...
WHOLE BODY - EXCERCISE

Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status

Year Published: 2018

Physical exercise induces inflammatory and oxidative markers production in the skeletal muscle and this process is under the control of both endogenous and exogenous modulators. Recently, molecular hydrogen (H2) has been described as a therapeutic gas able to reduced oxidative stress in a number of conditions. However, nothing is known about its putative role in the inflammatory and oxidative ...
KIDNEY - SURGERY/TRANSPLANTATION

Dual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From ...

Year Published: 2018

Background: Hydrogen (H2) and carbon monoxide (CO) gas are both reported to reduce reactive oxygen species and alleviate tissue ischemia-reperfusion (I-R) injury. The present study was conducted to evaluate the effects of a mixture of H2 gas and CO gas (dual gas) in comparison with hydrogen gas (H2: 2%) alone on I-R renal injury (composition of dual gas; N2: 77.8%; O2: 20.9%; H2: 1.30%; CO: 250 ...
BRAIN - SLEEP APNEA

Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting ...

Year Published: 2018

Obstructive sleep apnea (OSA) is a very common breathing and sleep disorder characterized by intermittent hypoxia (IH), which is often associated with behavioral and neurocognitive functions impairment. Hydrogen (H2), as a novel and effective antioxidant, is reported to be a potential neuroprotective agent. The aim of this study is to investigate whether H2 could improve CIH-induced neurocognitive ...
BRAIN - DIABETES

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat ...

Year Published: 2018

Diabetic peripheral neuropathy (DPN) is considered to be the most common cause of microvascular diabetic complications, for which no effective therapies currently exist. Previous studies have identified that oxidative stress is the common pathway in all possible hypotheses for the induction of DPN, and poly(ADP‑ribose) (PAR) polymerase‑1 (PARP‑1)‑dependent cell death (parthanatos) is key ...
HEART - HEART FAILURE

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative ...

Year Published: 2018

Background: Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF. Methods and Results: A total of 60 Sprague-Dawley (SD) rats ...
LUNG - CANCER

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury ...

Year Published: 2019

Although inhibition of epidermal growth factor receptor (EGFR)-mediated cell signaling by the EGFR tyrosine kinase inhibitor gefitinib is highly effective against advanced non-small cell lung cancer, this drug might promote severe acute interstitial pneumonia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive anti-oxidant. Here, we show that treatment with H2 ...