search - Hydrogen Studies

Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress

Year Published: 2013

Background: Reactive oxygen species (ROS) are often associated with persistent pains such as neuropathic and inflammatory pain. Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). Methods: ...

EYE - DIABETES

Hydrogen-Rich Saline Prevents Early Neurovascular Dysfunction Resulting from Inhibition of Oxidative ...

Year Published: 2013

Purpose: Diabetic retinopathy (DR) is characterized by increased oxidative and nitrosative stress, both of which lead to neurotoxicity and vascular permeability. Previous studies on a variety of organs indicate that hydrogen-rich saline not only has considerable antioxidant and anti-inflammatory properties, but also suppresses oxidative stress-induced injury. In the present study, we assessed the ...

BRAIN - CARDIAC ARREST

The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest

Year Published: 2013

Objective: The purpose of this study was to investigate the neuroprotective effects of intraperitoneal injection of hydrogen (H2) in rabbits with cardiac arrest (CA). Methods: A rabbit model of CA was established by the delivery of alternating current between the esophagus and chest wall to induce ventricular fibrillation. Before CA, the animals were randomly divided into four groups: a sham group ...

BRAIN - STROKE

Hydrogen Inhalation Ameliorated Mast Cell–Mediated Brain Injury After Intracerebral Hemorrhage in ...

Year Published: 2013

Objective: Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to antioxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage. Design: Controlled in vivo laboratory study. Setting: Animal research ...

BRAIN - PARKINSON'S DISEASE

Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

Year Published: 2013

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable ...

BRAIN - BRAIN INJURY

The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion

Year Published: 2013

In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with a ...

BRAIN - BRAIN INJURY

Delayed Neurovascular Dysfunction Is Alleviated by Hydrogen in Asphyxiated Newborn Pigs

Year Published: 2013

Background: The neurovascular unit encompasses the functional interactions of cerebrovascular and brain parenchymal cells necessary for the metabolic homeostasis of neurons. Previous studies indicated marked but only transient (1-4 h) reactive oxygen species-dependent neurovascular dysfunction in newborn pigs after severe hypoxic/ischemic (H/I) stress contributing to the neuronal injury after ...

BRAIN - ENVIRONMENTAL POLLUTION

Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning

Year Published: 2013

Background: Studies have shown that inhalation of hydrogen gas, which acts as an antioxidant, can protect the brain against free radicals in rats with ischemia-reperfusion. The neuronal damage caused by acute carbon monoxide (CO) poisoning is partly free radical mediated. We hypothesize that hydrogen may prevent neurological damage from CO poisoning. Objectives: This study is designed to test ...

BRAIN - NEUROPROTECTION

Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis ...

Year Published: 2013

Background: In animal models, several anesthetics induce widespread increases in neuronal apoptosis in the developing brain with subsequent neurologic deficits. Although the mechanisms are largely unknown, the neurotoxicity may, at least in part, be due to elevated oxidative stress caused by mitochondrial dysfunction. In an investigation of potential therapies that could protect against this type ...

BRAIN - STROKE

Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by ...

Year Published: 2013

Molecular hydrogen has been proved effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species. Lactulose can produce considerable amount of hydrogen through fermentation by the bacteria in the gastrointestinal tract. To determine the neuroprotective effects of lactulose against cerebral I/R injury in rats and explore the probable ...

SPINE - SURGERY/TRANSPLANTATION

Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in ...

Year Published: 2013

Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage. The present study was designed to investigate the beneficial effects of HS against spinal cord I/R injury and its associated mechanisms. Spinal cord ischemia was induced by infrarenal aortic occlusion for 20min in male New Zealand white rabbits. Different doses of HS were ...

BRAIN - BRAIN INJURY

Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on ...

Year Published: 2013

Early brain injury (EBI), a significant contributor to poor outcome after subarachnoid hemorrhage (SAH), is intimately associated with neuronal apoptosis. Recently, the protective role of hydrogen (H2 ) in the brain has been widely studied, but the underlying mechanism remains elusive. Numerous studies have shown nuclear factor-κB (NF-κB) as a crucial survival pathway in neurons. Here we ...

BRAIN - BRAIN INJURY

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via ...

Year Published: 2012

To investigate the effects of inhalation of hydrogen gas on cognitive impairment induced by transient cerebral ischemia and its potential mechanism. Two-vessel occlusion rat model was used to produce 10-minute transient global cerebral ischemia. One hundred and twenty male Wistar rats were randomly divided into sham, sham+H(2), ischemia, and ischemia+H(2) groups (n = 30 each group). Inhalation of ...

HEART - CARDIAC ARREST

H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic ...

Year Published: 2012

All clinical and biological manifestations related to postcardiac arrest (CA) syndrome are attributed to ischemia-reperfusion injury in various organs including brain and heart. Molecular hydrogen (H(2)) has potential as a novel antioxidant. This study tested the hypothesis that inhalation of H(2) gas starting at the beginning of cardiopulmonary resuscitation (CPR) could improve the outcome of CA. ...

BRAIN - BRAIN INJURY

Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid ...

Year Published: 2012

Cerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H(2)) can selectively reduce levels of hydroxyl radicals (·OH) and ...

BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic ...

Year Published: 2012

Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events that result in protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect the brain against oxidative damage and modulate the capacity of the brain to cope with synaptic dysfunction and cognitive impairment. However, no studies have investigated the effects of hydrogen-rich ...

BRAIN - TRAUMATIC BRAIN INJURY

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing ...

Year Published: 2012

Background: Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS. Our recent study shows that H(2) inhalation is beneficial to traumatic brain injury (TBI) via reducing oxidative stress. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable ...

BRAIN - STROKE

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via ...

Year Published: 2012

Hydrogen gas (H(2)) as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable for clinical application. The present study was designed to investigate whether HS can offer a neuroprotective effect in a rat model of permanent focal cerebral ischemia and what mechanism(s) ...

BRAIN - BRAIN INJURY

Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia.

Year Published: 2012

Global cerebral ischemia and reperfusion (I/R) often result in high mortality. Free radicals have been reported to play an important role in global cerebral I/R, and therefore, reduction of these might improve the outcome. Here, we investigated the effect of hydrogen gas (H2) (a strong free radical scavenger) on the survival rate of mice following global cerebral I/R. We further examined the ...

EAR - HEARING LOSS

Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils

Year Published: 2012

Aim: Auditory neuropathy (AN) is a hearing disorder characterized by abnormal auditory nerve function with preservation of normal cochlear hair cells. This study was designed to investigate whether treatment with molecular hydrogen (H(2)), which can remedy damage in various organs via reducing oxidative stress, inflammation and apoptosis, is beneficial to ouabain-induced AN in gerbils. Methods: AN ...

BRAIN - SEPSIS

Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness ...

Year Published: 2012

Molecular hydrogen has been shown to have neuroprotective effects in mouse models of acute neurodegeneration. The effect was suggested to be mediated by its free-radical scavenger properties. However, it has been shown recently that molecular hydrogen alters gene expression and protein phosphorylation. The aim of this study was to test whether chronic ad libitum consumption of molecular ...

BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide ...

Year Published: 2012

This experiment was designed to determine whether hydrogen (H(2)) rich saline can ameliorate brain abnormalities in a rat model with acute carbon monoxide (CO) poisoning. Sprague-Dawley male rats were used for CO poisoning and H(2) rich saline treatment. Changes in neurons, microglias, and myelin sheath were observed by electron microscope. Neuron loss was assessed by Nissl staining. Antioxidant ...

BRAIN - BRAIN INJURY

Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in ...

Year Published: 2012

Hydrogen gas has been demonstrated to neutralize free radicals and reduce oxidative stress recently. Our objective was to determine the therapeutic effect of H2 inhalation and its antioxidative activity on early brain injury after subarachnoid hemorrhage. Controlled in vivo laboratory study. Animal research laboratory. One hundred thirty-seven adult male Sprague-Dawley rats weighing 280-350 g. ...

EAR - HEARING LOSS

Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs

Year Published: 2012

To examine the efficiency of hydrogen-rich saline in the treatment of intensive noise-induced cochlear injury. Forty guinea pigs were assigned to one of four groups: HS+NOISE (i.p. injection hydrogen-rich saline), NS+NOISE (i.p. injection normal saline), NOISE ALONE (noise control), and NO TREATMENT (normal control) groups. The HS+NOISE, NS+NOISE, and NOISE ALONE groups were exposed to intensive ...

BRAIN - BRAIN INJURY

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema ...

Year Published: 2012

Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on ...