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Studies Found: 230

BRAIN - CHRONIC FATIGUE SYNDROME

Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four ...

Year Published: 2024

No abstract available
BRAIN - RADIOPROTECTION

Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism ...

Year Published: 2023

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by coupling the brain metabolomics and biological target network methods. Methods and results: HRW significantly improves the cognitive impairment in rats exposed to ionizing ...
BRAIN - STROKE

Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the ...

Year Published: 2023

This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on neurological function in mice with cerebral ischemia were evaluated by neurological function scores. Infarct volume and histological damage were evaluated by 2,3,5‑triphenyl tetrazolium chloride staining (TTC staining). Golgi‑Cox ...
BRAIN - SEPSIS

Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat ...

Year Published: 2023

Sepsis-associated encephalopathy (SAE) is characterised by long-term cognitive impairment and psychiatric illness in sepsis survivors, associated with increased morbidity and mortality. There is a lack of effective therapeutics for SAE. Molecular hydrogen (H2) plays multiple roles in septic diseases by regulating neuroinflammation, reducing oxidative stress parameters, regulating signalling ...
BRAIN - OBESITY

Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans

Year Published: 2023

Introduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation. Methods: A 1.5-T single-voxel proton magnetic resonance ...
BRAIN - ALZHEIMER'S DISEASE

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, ...

Year Published: 2023

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected ...
BRAIN - BRAIN INJURY

Hydrogen-rich water reduces cell damage by reducing excessive autophagy in mouse neuronal cells ...

Year Published: 2023

Objective: To investigate whether hydrogen-rich water exerts a protective effect against cellular injury by affecting the level of autophagy after oxygen glucose deprivation/reoxygenation (OGD/R) in a mouse hippocampal neuronal cell line (HT22 cells). Methods: HT22 cells in logarithmic growth phase were cultured in vitro. Cell viability was detected by cell counting kit-8 (CCK-8) assay to find the ...
BRAIN - BRAIN INJURY

Hydrogen-Rich Saline-A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral ...

Year Published: 2023

Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process. Recent findings suggest that reactive oxygen species (ROS) are essential secondary messengers that activate the NLRP3 inflammasome. Hydrogen-rich saline (HS) ...
BRAIN - SEPSIS

Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated ...

Year Published: 2023

Hydrogen (H2) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. We examined whether it is related to PPARα and its regulatory targets, ABC efflux transporters. After injection with DMSO/GW6471 (a PPARα inhibitor), the mice subjected to sham/caecal ligation and puncture (CLP) surgery were treated with H2 for 60 ...
BRAIN - SEPSIS

Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates ...

Year Published: 2023

Sepsis is associated with numerous physiological and biochemical abnormalities that result in a life-threatening condition. The involvement of the Central Nervous System (CNS) during sepsis has received considerable attention, especially the hippocampus which plays a key role in the learning and memory processes. The increased interest in this limbic region during systemic inflammation (SI) is ...
BRAIN - ALZHEIMER'S DISEASE

Efficacy of donepezil plus hydrogen-oxygen mixture inhalation for treatment of patients with ...

Year Published: 2023

To investigate the clinical effect of donepezil combined with hydrogen-oxygen mixture inhalation in the treatment of patients with Alzheimer disease (AD), a total of 273 AD patients admitted to our hospital from March 2018 to March 2022 were retrospectively analyzed and assigned into an observation group (n = 138) and a control group (n = 135) according to the different treatment that they ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen gas on NOD-like receptor protein 3 inflammasomes in the cerebral cortex of rats ...

Year Published: 2023

Objective: To investigate the effect of hydrogen gas on NOD-like receptor protein 3 (NLRP3) inflammasomes in the cerebral cortex of rats with traumatic brain injury (TBI). Methods: 120 adult male Sprague-Dawley (SD) rates were randomly divided into 5 groups (n = 24): sham operation group (S group), TBI model group (T group), TBI+NLRP3 inhibitor MCC950 group (T+M group), TBI+hydrogen gas group (T+H ...
BRAIN - STROKE

The Role of LincRNA-EPS/Sirt1/Autophagy Pathway in the Neuroprotection Process by Hydrogen against ...

Year Published: 2023

Cerebral ischemia/reperfusion (CI/R) injury causes high disability and mortality. Hydrogen (H2) enhances tolerance to an announced ischemic event; however, the therapeutic targets for the effective treatment of CI/R injury remain uncertain. Long non-coding RNA lincRNA-erythroid prosurvival (EPS) (lincRNA-EPS) regulate various biological processes, but their involvement in the effects of H2 and ...
BRAIN - PARKINSON'S DISEASE

Effects of hydrogen gas inhalation on L-DOPA-induced dyskinesia

Year Published: 2023

L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is a side effect of Parkinson's disease treatment and it is characterized by atypical involuntary movements. A link between neuroinflammation and L-DOPA-induced dyskinesia has been documented. Hydrogen gas (H2) has neuroprotective effects in Parkinson's disease models and has a major anti-inflammatory effect. Our objective is to test the ...
BRAIN - NEUROPROTECTION

Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage ...

Year Published: 2023

The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. In a clinical trial of inhaled hydrogen in patients with subarachnoid hemorrhage (SAH), we found that hydrogen reduced the accumulation of lactic acid in the nervous system. There are no studies demonstrating the regulatory effect of hydrogen on lactate and in this study we hope to further ...
BRAIN - BRAIN INJURY

Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against ...

Year Published: 2023

Background: Excessive doses of electromagnetic radiation pose a negative impact on the central nervous system and lead to mental disorders. Molecular hydrogen can scavenge intracellular hydroxyl radicals, acting as an antioxidant, anti-apoptotic and anti-inflammatory agent. We seek to assess the capability of molecular hydrogen to ameliorate brain damage induced by electromagnetic radiation. ...
BRAIN - BRAIN INJURY

Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and ...

Year Published: 2023

We previously reported the neuroprotective potential of combined hydrogen (H2) gas ventilation therapy and therapeutic hypothermia (TH) by assessing the short-term neurological outcomes and histological findings of 5-day neonatal hypoxic-ischemic (HI) encephalopathy piglets. However, the effects of H2 gas on cerebral circulation and oxygen metabolism and on prognosis were unknown. Here, we used ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly ...

Year Published: 2022

Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls. Methods: A total of 184 patients aged ≥ 65 years were enrolled and ...
BRAIN - SEPSIS

Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated ...

Year Published: 2023

Background: Sepsis-associated encephalopathy (SAE) is a complication of the central nervous system in patients with sepsis. Currently, no effective treatment for sepsis is available. Hydrogen plays a protective role in different diseases; however, the detailed mechanism of hydrogen-treated disease remains unclear. The purpose of this study was to investigate the effect of hydrogen on SAE in vitro ...
BRAIN - CARDIAC ARREST

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac ...

Year Published: 2023

Background: Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA). Methods: HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals ...
BRAIN - ALZHEIMER'S DISEASE

Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent ...

Year Published: 2023

(1) Background: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as anti-oxidant, anti-inflammation, anti-cell death, and the stimulation of energy metabolism. To develop a disease-modifying treatment for AD through multifactorial mechanisms, an open label pilot study on H2 treatment was ...
BRAIN - SEPSIS

Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau ...

Year Published: 2023

Background: Sepsis-associated encephalopathy (SAE) is a cognitive dysfunction caused by sepsis. Hyperphosphorylated tau is considered to play a significant role in the progression of neurodegenerative disease and also contributes to cognitive dysfunction in septic mice. Molecular hydrogen (H2) plays an antioxidant and anti-inflammatory role, and plays a protective role in septic mice. This study ...
BRAIN - BRAIN INJURY

Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect ...

Year Published: 2022

Intraperitoneal administration of hydrogen (H2)-containing saline inhibited neuronal cell death in ischemic stroke in a number of animal models, but it is unknown whether H2 is absorbed from the abdominal cavity into the blood and reaches the brain. In this study, we investigated whether intraperitoneal administration of saline containing H2 inhibits neuronal cell death caused by cerebral ischemia ...
BRAIN - GUT MICROBIOME

Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut ...

Year Published: 2022

Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2 ), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis. Aim: ...
BRAIN - SEPSIS

Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of ...

Year Published: 2022

Background: Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low quality of life, and long-term neurological sequelae in suspected patients. At present there is no specific treatment for SAE rather than supportive therapy and judicious use of ...