Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-in-Human Pilot Study
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DOI:
10.1253/circj.CJ-16-0127
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Abstract:
Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.Methods and
Results:Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.
| Publish Year | 2016 |
|---|---|
| Country | Japan |
| Rank | Positive |
| Journal | Circulation Journal |
| Primary Topic | Heart |
| Secondary Topic | Cardiac Arrest |
| Model | Human |
| Tertiary Topic | Hydrogen Safety |
| Vehicle | Gas |
| pH | N/A |
| Application | Inhalation |
| Comparison | |
| Complement |