Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
Read more:
DOI:
10.1038/s41598-018-35239-0
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
The main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Recent studies showed that senescent cells are involved in the development and progression of atherosclerosis, and eliminating senescent cells suppresses the senescence-associated secretory phenotype. We previously reported that molecular hydrogen-rich water (HW) has antioxidant and anti-inflammatory effects in numerous diseases. Here, we used LDL receptor-deficient mice fed a high-fat diet (HFD) for 13 weeks as a model for atherosclerosis and evaluated the effects of continuous administration of HW. The numbers of endothelial cells in the atheroma expressing the senescence factors p16INK4a and p21 decreased in HFD-fed mice given HW compared with HFD-fed mice given control water. Furthermore, macrophage infiltration and Tnfα expression in the atheroma were also suppressed. These results suggest that vascular aging can be suppressed by HW.| Publish Year | 2018 |
|---|---|
| Country | Japan |
| Rank | Positive |
| Journal | Nature Scientific Reports |
| Primary Topic | Heart |
| Secondary Topic | Atherosclerosis |
| Model | Mouse |
| Tertiary Topic | Oxidative Stress |
| Vehicle | Water (Dissolved) |
| pH | Neutral |
| Application | Ingestion |
| Comparison | |
| Complement |