Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision

Alessio Ferrone, Alfredo Grilli, Antonia Patruno, Daniela Maria Pia Gatta, Ester Vitacolonna, Giuseppe Di Martino, Lorenza Speranza, Maria Anna De Lutiis, Mario Felaco, Marta Di Nicola, Mirko Pesce, Sara Franceschelli

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DOI: 10.1111/jcmm.13569 DOI is the universal ID for this study.

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Gastroesophageal reflux disease (GERD), a clinical condition characterized by reflux of gastroduodenal contents in the oesophagus, has proved to demonstrate a strong link between oxidative stress and the development of GERD. Proton pump inhibitors (PPIs) have been universally accepted as first-line therapy for management of GERD. The potential benefits of electrolysed reduced water (ERW), rich in molecular hydrogen, in improving symptoms and systemic oxidative stress associated with GERD was assessed. The study was performed on 84 GERD patients undergoing control treatment (PPI + tap water) or experimental treatment (PPI + ERW) for 3 months. These patients were subjected to the GERD-Health Related Quality of Life Questionnaire as well as derivatives reactive oxigen metabolites (d-ROMs) test, biological antioxidant potential (BAP) test, superoxide anion, nitric oxide and malondialdehyde assays, which were all performed as a proxy for the oxidative/nitrosative stress and the antioxidant potential status. Spearman's correlation coefficient was used to evaluate the correlation between scores and laboratory parameters. Overall results demonstrated that an optimal oxidative balance can be restored and GERD symptoms can be reduced rapidly via the integration of ERW in GERD patients. The relative variation of heartburn and regurgitation score was significantly correlated with laboratory parameters. Thus, in the selected patients, combination treatment with PPI and ERW improves the cellular redox state leading to the improvement of the quality of life as demonstrated by the correlation analysis between laboratory parameters and GERD symptoms.

Publish Year 2018
Country Italy
Rank Positive
Journal Journal of Cellular and Molecular Medicine
Primary Topic Stomach
Secondary TopicGastroesophageal Reflux Disease
Model Human
Tertiary TopicOxidative Stress
Vehicle Water (Electrolysis)
pH Alkaline
Application Ingestion